S. Hao

pH-Sensitive Nanodroplets for Controlled Delivery of Berberine Chloride

This paper develops pH-sensitive nanodroplets for controlled berberine chloride delivery, showing high encapsulation efficiency and ultrasound-enhanced release.

Fertilization-induced synergid cell death by RALF12-triggered ROS production and ethylene signaling

This study identifies RALF12-triggered ROS production and ethylene signaling as mechanisms causing synergid cell death during fertilization in maize.

Identification of Host Restriction Factors Critical for Recombinant AAV Transduction of Polarized Human Airway Epithelium

This study identifies host restriction factors critical for rAAV2.5T transduction of polarized human airway epithelium, revealing KIAA0319L's role in transduction but not internalization, and WDR63's role in transduction without involvement in internalization or nuclear entry.

Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5' untranslated region

The paper develops cgSHAPE-seq to identify RNA-binding sites of coumarin derivatives targeting SARS-CoV-2 5' UTR and demonstrates their use as RNA-degrading chimeras to reduce viral RNA expression.

YAP condensates are highly organized hubs for YAP/TEAD transcription

This study shows YAP forms organized condensates under Hippo pathway and actin tension, which stabilize YAP and recruit coactivators to enhance transcription.

Longitudinal Morphological and Functional Characterization of Human Heart Organoids Using Optical Coherence Tomography

This study uses optical coherence tomography to track the morphological and functional development of human heart organoids over time.

Microbiota-instructed regulatory T cell differentiation is mediated by a distinct RORγt+ antigen presenting cell subset

This study identifies a distinct RORγt+ antigen presenting cell subset that mediates microbiota-driven regulatory T cell differentiation, revealing a mechanism for maintaining immune tolerance.

Single-cell Stereo-seq enables cell type-specific spatial transcriptome characterization in Arabidopsis leaves

This study introduces scStereo-seq, a method for single-cell spatial transcriptome profiling in Arabidopsis leaves, revealing cell type-specific spatial gene expression gradients and developmental trajectories.

Targeting interleukin-1 for reversing fat browning and muscle wasting in infantile nephropathic cystinosis

This paper shows that anakinra, an IL-1 receptor antagonist, reduces fat browning and muscle wasting in Ctns-/- mice, suggesting it could treat cachexia in infantile nephropathic cystinosis.

The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

This study shows that blocking IL-1 receptor reduces adipose browning and muscle wasting in CKD-associated cachexia in mice.

The SARS-CoV-2 transcriptome and the dynamics of the S gene furin cleavage site in primary human airway epithelia

This study examines the SARS-CoV-2 transcriptome in human airway epithelia, identifying frequent deletions at the S1/S2 boundary and their dynamics in virions.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

Long Period Modeling SARS-CoV-2 Infection of in Vitro Cultured Polarized Human Airway Epithelium

This study shows that SARS-CoV-2 infection of polarized human airway epithelium is long-lasting with recurring replication peaks every 7-10 days and requires a high viral load.

Metagenomic Next-Generation Sequencing of Rectal Swabs for the Surveillance of Antimicrobial Resistant Organisms on the Illumina Miseq and Oxford MinION Platforms

This study evaluates mNGS on Illumina MiSeq and Nanopore MinION platforms for detecting MDRO in rectal swabs, showing concordance with culture results and highlighting advantages of both short and long-read approaches.

Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway

This study shows that deleting Nupr1 in HSCs activates quiescence, enhancing engraftment without affecting stemness or differentiation.

An enormous Paris polyphylla genome sheds light on genome size evolution and polyphyllin biogenesis

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

Establishment of a Replicon System for Bourbon Virus and Identification of Small Molecules that Efficiently Inhibit Virus Replication

This study establishes a BRBV replicon system and identifies myricetin as a potent inhibitor of BRBV replication with a high therapeutic index.

Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment

This study shows that intra-BM MSC transfusion restores the BM microenvironment, suppresses leukemia, and reprograms macrophages to reduce tumor burden.

Quantitative LCMS for ceramides/dihydroceramides: pregnancy baseline biomarkers and potential metabolic messengers

This paper develops and validates an LC/MS/MS method to quantify ceramides and dihydroceramides in human serum, revealing unique gestational patterns during pregnancy.

High Throughput pMHC-I Tetramer Library Production Using Chaperone Mediated Peptide Exchange

The paper introduces a method to produce pMHC-I tetramer libraries using TAPBPR chaperone-mediated peptide exchange, enabling high-throughput analysis of TCR repertoires and pMHC-I specificities.