Author

T. Hashiguchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

R. Suzuki· 3 shared A. Saito· 2 shared B. Lee· 2 shared H. Ito· 2 shared H. Nasser· 2 shared J. Ito· 2 shared J. Sasaki· 2 shared K. Matsuno· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

R. Suzuki

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Virological characteristics of the SARS-CoV-2 XBB.1.5 variant

T. Tamura, T. Irie, S. Deguchi, H. Yajima, M. Tsuda, H. Nasser, K. Mizuma, A. Plianchaisuk, S. Suzuki, K. Uriu, M. M. Begum, R. Shimizu, M. Jonathan, R. Suzuki, T. Kondo, , T. Fukuhara

The paper analyzes the virological characteristics of the SARS-CoV-2 XBB.1.5 variant, showing reduced pathogenicity and impaired MHC expression due to mutations in ORF8 and S.

bioRxiv · Aug 16, 2023 · PreprintMicrobiology

Virological characteristics of the novel SARS-CoV-2 Omicron variants including BA.2.12.1, BA.4 and BA.5

I. Kimura, D. Yamasoba, T. Tamura, N. Nao, Y. Oda, S. Mitoma, J. Ito, H. Nasser, J. Zahradnik, K. Uriu, S. Fujita, Y. Kosugi, L. Wang, M. Tsuda, M. Kishimoto, , K. Sato

This study analyzes the virological characteristics of SARS-CoV-2 Omicron variants BA.2.12.1, BA.4, and BA.5, finding they have higher reproduction numbers, reduced neutralization by prior immunity, increased replication in lung cells, and greater pathogenicity in hamsters compared to BA.2.

bioRxiv · May 26, 2022Microbiology

Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology

T. Hemmi, A. Ainai, T. Hashiguchi, M. Tobiume, T. Kanno, N. Iwata-Yoshikawa, S. Iida, Y. Sato, S. Miyamoto, A. Ueno, K. Sano, S. Saito, N. Shiwa-Sudo, N. Nagata, K. Tamura, , T. Suzuki

This study shows that an intranasal vaccine with CpG ODN2006 induces secretory IgA antibodies against SARS-CoV-2 variants and reduces lung eosinophilic immunopathology compared to subcutaneous vaccination.

bioRxiv · May 24, 2022Microbiology

Germinal center-derived broadly neutralizing antibodies adapt to SARS-CoV-2 antigenic drift

K. Shitaoka, Y. Kawano, A. Higashiura, Y. Mizoguchi, T. Hashiguchi, N. Nishimichi, S. Huang, A. Ito, A. Yamamoto, S. Ohki, M. Kanda, T. Taniguchi, Y. Yokosaki, S. Okada, T. Sakaguchi, T. Yasuda

The paper identifies neutralizing antibodies from early SARS-CoV-2 infections that retain activity against Omicron and other variants, highlighting the role of germinal center mutations in their broad neutralization.

bioRxiv · Jan 26, 2022 · PreprintImmunology

Assessing the zoonotic potential of a novel bat morbillivirus

S. Ikegame, J. C. Carmichael, H. Wells, R. L. Furler O'Brien, J. A. Acklin, H.-P. Chiu, K. Y. Oguntuyo, R. M. Cox, A. R. Patel, S. Kowdle, C. S. Stevens, M. Eckley, S. Zhan, J. K. Lim, E. C. Veit, , B. Lee

This study identifies a novel bat morbillivirus, MBaMV, and assesses its zoonotic potential by showing it can infect human cells but is restricted by human immune responses.

bioRxiv · Sep 17, 2021 · PreprintMicrobiology

Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes

S. Ikegame, T. Hashiguchi, C.-t. Hung, K. Dobrindt, K. Brennand, M. Takeda, B. Lee

The paper identifies hyperfusogenic measles virus F protein mutants associated with neuropathogenic phenotypes through a saturating mutagenesis screen.

bioRxiv · Dec 22, 2020Microbiology