Author

H. Hefzi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Approach:experimental assay· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

N. E. Lewis· 3 shared G. M. Lee· 2 shared H. F. Kildegaard· 2 shared J. S. Lee· 2 shared K. J. l. C. Karottki· 2 shared L. E. Pedersen· 2 shared P. Spahn· 2 shared S. Li· 2 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

N. E. Lewis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening

S. H. Kim, S. Shin, M. Baek, K. Xiong, K. J. l. C. Karottki, H. Hefzi, L. M. Grav, L. E. Pedersen, H. F. Kildegaard, N. E. Lewis, J. S. Lee, G. M. Lee

The paper identifies hyperosmotic stress-responsive genes in CHO cells using CRISPR/Cas9 screening and validates their role in stress resistance and protein production.

bioRxiv · Dec 13, 2022Bioengineering

Restoration of deficient DNA Repair Genes Mitigates Genome Instability and Increases Productivity of Chinese Hamster Ovary Cells

P. Spahn, X. Zhang, Q. Hu, N. Hamaker, H. Hefzi, S. Li, C.-C. Kuo, Y. Huang, J. Lee, P. Ly, K. Lee, N. E. Lewis

This study restores DNA repair genes in CHO cells, improving genome stability and protein titer.

bioRxiv · Jan 7, 2021 · PreprintCell Biology

A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes

K. J. l. C. Karottki, H. Hefzi, S. Li, L. E. Pedersen, P. Spahn, C. Joshi, D. Ruckerbauer, J. H. Bort, A. Thomas, J. S. Lee, N. Borth, G. M. Lee, H. F. Kildegaard, N. E. Lewis

The paper uses a CRISPR-Cas9 screen in Chinese hamster ovary cells to identify glutamine-sensitive genes, revealing a novel lipase involved in TCA cycle regulation.

bioRxiv · May 7, 2020Bioengineering