ImmunologybioRxiv
Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis
P. Sharma, R. D. Sharma, B. Sarkar…·D. Kumar
This study identifies IL-17 and COX2 as negative regulators of protective immunity in tuberculosis, showing that Ly6G+ granulocytes are a major source of IL-17 and their inhibition reduces bacterial burden and pathology.