M. Bui

Peristromal niches protect lung cancers from targeted therapies through a combined effect of multiple molecular mediators

This study shows that stromal niches protect lung cancers from ALK inhibitors through multiple mechanisms, and targeting these mechanisms together is more effective than targeting them individually.

CRISPR/Cas9-mediated mutagenesis of the Asian Citrus Psyllid, Diaphorina citri

This paper develops CRISPR/Cas9 methods for genetic modification of Diaphorina citri to combat Huanglongbing disease spread.

Engineered Antiviral Sensor Targets Infected Mosquitoes

The paper develops REAPER, a Cas13-based antiviral sensor that kills infected mosquitoes upon activation by arbovirus infection.

CRISPR Mediated Transactivation in the Human Disease Vector Aedes aegypti

This paper develops a CRISPRa system in Aedes aegypti to transactivate endogenous genes, demonstrating its ability to overexpress developmental genes and suppress dengue virus.

Developmental regulation of mitotic chromosome formation revealed by condensin reporter mice

The paper investigates developmental regulation of mitotic chromosome formation using condensin reporter mice but retracts findings due to experimental artifacts related to cell-type differences.

Spontaneous Cell Fusions as a Mechanism of Parasexual Recombination in Tumor Cell Populations

This study investigates spontaneous cell fusions in tumor cell populations as a mechanism of parasexual recombination, finding evidence of low-frequency fusions and their role in increasing clonal heterogeneity.

The ratio between centromeric proteins CENP-A and CENP-C maintains homeostasis of human centromeres

The paper shows that maintaining the CENP-A to CENP-C ratio is critical for centromere homeostasis, as disrupting this balance causes mitotic defects.

Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners

The paper investigates how histone variants encode intrinsic elasticity in nucleosomes and how their binding partners modulate this elasticity and chromatin compaction.

Development of a Confinable Gene-Drive System in the Human Disease Vector, Aedes aegypti.

This paper develops CRISPR-based split-gene drives in Aedes aegypti with high cleavage and transmission rates, demonstrating their potential for safe and reversible population control.

Germline Cas9 Expression Yields Highly Efficient Genome Engineering in a Major Worldwide Disease Vector, Aedes aegypti

This paper develops transgenic Cas9 lines in Aedes aegypti for efficient genome editing, enabling high-throughput gene disruption and potential gene drive applications.

Internal modifications in the CENP-A nucleosome modulate centromeric dynamics

This study investigates how acetylation and methylation of CENP-A lysine 124 affect centromere dynamics, mitotic fidelity, and replication timing.