J. Aube

MAIT Cells Modulate Innate Immune Cells and Inhibit Colon Cancer Growth

This study shows MAIT cells inhibit colon cancer growth in mice by modulating immune responses and increasing eosinophil-related cytokines.

SETD2 maintains nuclear lamina stability to safeguard the genome

This study identifies a non-catalytic function of SETD2 in maintaining nuclear lamina stability and genome integrity through its N-terminus interactions.

Enhancing Mucosal-Associated Invariant T (MAIT) cell function and expansion with human selective serum

This study compares the effects of Physiologix XF SR and fetal bovine serum on MAIT cell expansion, finding that Phx enhances proliferative capacity and functional responses.

AGC Kinase Inhibitors Regulate STING Signaling Through SGK-Dependent and SGK-Independent Mechanisms

This study identifies Sanofi-14h, an AGC kinase inhibitor, as a regulator of STING signaling that acts through both SGK-dependent and SGK-independent mechanisms to suppress IFNβ expression.

Use of a MAIT activating ligand, 5-OP-RU, as a mucosal adjuvant in a murine model of Vibrio cholerae O1 vaccination.

This study tests 5-OP-RU as a mucosal adjuvant in a murine cholera vaccine model, showing increased MAIT cell expansion but limited antibody response improvements.

Role of Ori in Thermococcus barophilus

This study investigates the role of the origin of replication (Ori) in Thermococcus barophilus, showing its necessity for DNA replication and growth under varying temperatures.

Single cell transcriptional profiling reveals helper, effector, and regulatory MAIT cell populations enriched during homeostasis and activation

This study uses single-cell RNA sequencing to identify distinct MAIT cell subtypes with different functional states during activation and infection.

Efficient 5-OP-RU-induced enrichment of Mucosal-associated invariant T cells in the murine lung does not enhance control of aerosol Mycobacterium tuberculosis infection.

This study shows that priming MAIT cells in mice with 5-OP-RU and P2C increases their activation and expansion but does not improve control of Mtb infection.