Author

L. Mazutis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 9 Assay:scRNA-seq· 8 Organism:human· 7 Research Focus:differential expression· 6 Approach:experimental assay· 6 Approach:statistical model· 6 Research Focus:cell-cell communication· 5 Organism:mouse· 4

Frequent Co-Authors

D. Pe'er· 7 shared I. Masilionis· 5 shared O. Chaudhary· 4 shared R. Chaligne· 4 shared M. Setty· 3 shared T. Nawy· 3 shared Y. Xie· 3 shared J. M. Chan· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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7 shared papersCancer Biology

D. Pe'er

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Progressive plasticity during colorectal cancer metastasis

A. Moorman, F. Cambuli, E. Benitez, Q. Jiang, Y. Xie, A. Mahmoud, M. Lumish, S. Hartner, S. Balkaran, J. Bermeo, S. Asawa, C. Firat, A. Saxena, A. Luthra, V. Sgambati, , K. Ganesh

This study identifies progressive plasticity in colorectal cancer metastases, showing reprogramming into fetal progenitor states and divergent differentiation, linked to poor survival.

bioRxiv · Aug 18, 2023Cancer Biology

Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals an invasive tumor vasculature phenotype

J. Zvirblyte, J. Nainys, S. Juzenas, R. Kubiliute, M. Kincius, A. Ulys, S. Jarmalaite, L. Mazutis

This study uses single-cell RNA sequencing to analyze ccRCC tumor microenvironment, identifying an invasive vasculature subpopulation linked to poor survival.

bioRxiv · Aug 9, 2023Cancer Biology

Epigenetic plasticity cooperates with emergent cell-cell interactions to drive neoplastic tissue remodeling in the pancreas

C. Burdziak, D. Alonso-Curbelo, T. Walle, F. M. Barriga, J. Reyes, Y. Xie, Z. Zhao, C. J. Zhao, H.-A. Chen, O. Chaudhary, I. Masilionis, Z.-N. Choo, V. Gao, W. Luan, A. Wuest, , D. Pe'er

The paper uses single-cell analysis to show that epigenetic plasticity and cell-cell interactions drive tissue remodeling in early pancreatic cancer.

bioRxiv · Jul 26, 2022Cancer Biology

Age-related epithelial defects limit thymic function and regeneration

A. I. Kousa, L. Jahn, K. Zhao, A. E. Flores, D. Granadier, K. Cooper, J. M. Sheridan, A. Lemarquis, L. Sikkema, K. V. Argyropoulos, J. Tsai, A. Lazrak, K. Nichols, N. Lee, R. Ghale, , M. R. van den Brink

The paper identifies age-related thymic epithelial cell states that impair thymic regeneration and immune function through spatial and single-cell transcriptomics.

bioRxiv · Dec 16, 2021Immunology

Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

W. Karthaus, J. Chan, M. Setty, J. Love, S. Zaidi, Z.-N. Choo, S. Persad, J. LaClair, K. Lawrence, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, R. Chaligne, D. Pe'er, C. Sawyers

This study identifies a pharmacological strategy to reverse lineage plasticity in prostate cancer by inhibiting FGFR and Janus kinase pathways.

bioRxiv · Nov 1, 2021 · PreprintCancer Biology

Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling

S. Zaidi, J. L. Zhao, J. M. Chan, M. P. Roudier, K. M. Wadosky, A. Gopalan, W. R. Karthaus, J. Choi, K. Lawrence, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, R. Chaligne, I. Linkov, , C. L. Sawyers

The paper identifies stem-like luminal cells with elevated JAK/STAT signaling as a source of multilineage plasticity in prostate cancer, offering a therapeutic target.

bioRxiv · Nov 1, 2021 · PreprintCancer Biology

Single cell profiling reveals novel tumor and myeloid subpopulations in small cell lung cancer

J. M. Chan, A. Quintanal-Villalonga, V. Gao, Y. Xie, V. Allaj, O. Chaudhary, I. Masilionis, J. Egger, A. Chow, T. Walle, M. Mattar, D. V. Yarlagadda, J. L. Wang, F. Uddin, M. Offin, , C. M. Rudin

The paper profiles single-cell transcriptomes of SCLC subtypes to identify novel tumor and myeloid subpopulations and their associations with metastasis and immune microenvironment changes.

bioRxiv · Dec 1, 2020Cancer Biology

Single cell transcriptional profiling reveals helper, effector, and regulatory MAIT cell populations enriched during homeostasis and activation

C. K. Vorkas, C. Krishna, K. Li, J. Aube, L. Mazutis, C. S. Leslie, M. Glickman

This study uses single-cell RNA sequencing to identify distinct MAIT cell subtypes with different functional states during activation and infection.

bioRxiv · Oct 22, 2020Immunology

A Chemical Probe of CARM1 Alters Epigenetic Plasticity against Breast Cancer Cell Invasion

X.-C. Cai, T. Zhang, E.-j. Kim, M. Jiang, K. Wang, J. Wang, S. Chen, N. Zhang, H. Wu, F. Li, C. C. dela Sena, H. Zheng, V. Vivcharuk, X. Niu, W. Zheng, , M. Luo

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

bioRxiv · Mar 27, 2019Biochemistry

Single-cell Map of Diverse Immune Phenotypes Driven by the Tumor Microenvironment

E. Azizi, A. J. Carr, G. Plitas, A. E. Cornish, C. Konopacki, S. Prabhakaran, J. Nainys, K. Wu, V. Kiseliovas, M. Setty, K. Choi, R. M. Fromme, P. Dao, P. T. McKenney, R. C. Wasti, , D. Pe'er

The paper maps immune cell phenotypes in breast cancer using single-cell RNA-seq and identifies continuous tumor-specific expansions driven by environmental cues.

bioRxiv · Apr 2, 2018Immunology