Author

J. Beesley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Research Focus:differential expression· 2

Frequent Co-Authors

G. Chenevix-Trench· 3 shared W. Shi· 3 shared A. Civitarese· 2 shared D. Black· 2 shared F. Al-Ejeh· 2 shared J. D. French· 2 shared M. Miranda· 2 shared S. Lakhani· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

G. Chenevix-Trench

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.

H. L. Mackay, H. R. Stone, K. Ellis, G. Ronson, K. Starowicz, A. J. Garvin, P. Van Eijk, A. Aitsiankova, S. Vijayendran, J. Beesley, E. Petermann, E. Brown, R. M. Densham, S. H. Reed, F. Dobbs, , J. R. Morris

This study identifies USP50 as a ubiquitin-binding protein that regulates helicase and nuclease activities during DNA replication to prevent fork collapse and maintain genomic stability.

bioRxiv · Jan 10, 2024Cancer Biology

The potential of Senicapoc, a KCNN4 inhibitor, for the prevention and treatment of breast cancer

G. Chenevix-Trench, K. Britt, C. Xiao, M. Miranda, W. Shi, J. Beesley, J. Saunus, A. Civitarese, D. Black, M. Ruppert, M. Perreira, S. Jackson, Z. Teale, D. Carter-Cusack, L. Kalinowski, , F. Al-Ejeh

This study investigates Senicapoc, a KCNN4 inhibitor, and finds it delays mammary tumor development and slows tumor growth in mouse models, suggesting potential for breast cancer prevention and treatment.

bioRxiv · Apr 25, 2023 · PreprintCancer Biology

Redefining normal breast cell populations using long noncoding RNAs

M. Bitar, I. S. Rivera, I. Pimentel de Almeida, W. Shi, K. Ferguson, J. Beesley, S. Lakhani, S. Edwards, J. D. French

This study identifies and characterizes long noncoding RNAs in normal breast tissue, showing their utility in distinguishing cell subpopulations and improving cancer subtype classification.

bioRxiv · Sep 6, 2022Cell Biology

CRISPR screens identify gene targets and drug repositioning opportunities at breast cancer risk loci

N. K. Tuano, J. Beesley, M. Manning, W. Shi, L. Malver-Ortega, J. Paynter, D. Black, A. Civitarese, K. McCue, A. Hatzipantelis, K. Hillman, S. Kaufmann, H. Sivakumaran, J. M. Polo, R. Reddel, , J. Rosenbluh

bioRxiv · Sep 7, 2021 · PreprintCancer Biology

Epigenome erosion drives neural crest-like phenotypic mimicry in triple-negative breast cancer and other SOX10+ malignancies

J. M. Saunus, X. M. De Luca, K. Northwood, A. Raghavendra, A. Hasson, A. E. McCart Reed, M. Lim, S. Lal, A. C. Vargas, J. R. Kutasovic, A. J. Dalley, M. Miranda, E. Kalaw, P. Kalita-de Croft, I. Gresshoff, , S. R. Lakhani

The paper identifies SOX10 expression in TNBC and other SOX10+ malignancies, linking it to epigenome erosion and neural crest-like phenotypic mimicry through promoter hypomethylation.

bioRxiv · Mar 30, 2021 · PreprintCancer Biology