S. Lal

Single-cell transcriptional and epigenetic mapping reveals cellular and molecular mechanisms driving non-ischemic cardiac fibrosis

This study uses single-cell multiomic analysis to identify transcriptional circuits driving non-ischemic cardiac fibrosis in mouse and human hearts, showing reversibility of fibrosis-related changes.

Stricturing Crohn's disease single-cell RNA sequencing reveals fibroblast heterogeneity and intercellular interactions

This study uses single-cell RNA sequencing to analyze fibroblast heterogeneity and interactions in Crohn's disease strictures, identifying CDH11 as a potential therapeutic target.

Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle.

This study identifies ALPK3's role in maintaining sarcomere integrity and proteostasis in striated muscle by localizing to the M-band and interacting with SQSTM1.

Epigenome erosion drives neural crest-like phenotypic mimicry in triple-negative breast cancer and other SOX10+ malignancies

The paper identifies SOX10 expression in TNBC and other SOX10+ malignancies, linking it to epigenome erosion and neural crest-like phenotypic mimicry through promoter hypomethylation.

Comprehensive mapping of the human cytokine gene regulatory network

The paper maps a comprehensive cytokine gene regulatory network using eY1H assays, identifying 1,380 TF-cytokine gene interactions and novel regulatory axes in immune diseases.

Deep Learning Strategies for Differential Expansion Microscopy

This paper describes machine learning strategies to extract morphological and biochemical information from differential expansion microscopy images.

RNA Binding Motif Protein 48 is required for U12 splicing and maize endosperm differentiation

This study identifies RBM48 as a U12 splicing factor in maize that promotes endosperm differentiation and interacts with U12 and U2 splicing factors.