J. Berman

Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans.

This study shows how azole resistance in Candida albicans evolves through copy number variation followed by KSR1 loss of heterozygosity, resulting in a >500-fold resistance increase.

Antifungal tolerance and resistance emerge at distinct drug concentrations and rely upon different aneuploid chromosomes

This study identifies that antifungal drug tolerance and resistance in Candida albicans emerge at different drug concentrations and are associated with distinct aneuploid chromosomes.

Phylogenomics reveals extensive misidentification of fungal strains from the genus Aspergillus

The paper uses genome-scale phylogenomics to analyze 711 Aspergillus genomes, revealing taxonomic issues and strain misidentifications.

Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds

This study characterizes the heterogeneous and adaptive cytoprotective responses of C. albicans to antifungal compounds using single-cell transcriptomics.

Regulation of heme utilization and homeostasis in Candida albicans

This study identifies Huf1 as a heme-responsive transcription factor in C. albicans that regulates both heme homeostasis and uptake from the environment.

An orthologous gene coevolution network provides insight into eukaryotic cellular and genomic structure and function

The paper constructs an orthologous gene coevolution network from 332 budding yeast species to explore eukaryotic cellular and genomic structure and function, revealing insights into gene connectivity and environmental fitness.

Candida albicans genetic background influences mean and heterogeneity of drug responses and genome stability during evolution to fluconazole

This study shows that genetic background in Candida albicans affects both the average adaptation and the variability of drug responses and genome size during evolution in fluconazole.

Extracellular ATP released from Candida albicans activates non-peptidergic neurons to augment host defense

This study shows that ATP released by Candida albicans activates non-peptidergic neurons to enhance anti-Candida immune responses.

Candida albicans dispersed cells signify a developmental state distinct from biofilm and planktonic phases

The paper identifies dispersed Candida albicans cells as a distinct developmental state with unique transcriptomic features compared to biofilm and planktonic phases.

Ploidy tug-of-war: evolutionary and genetic environments influence the rate of ploidy drive in a human fungal pathogen

This study investigates how environmental and genetic factors influence ploidy drive in Candida albicans by evolving strains under different nutrient limitations.