Author

R. Olmer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Bioengineering· 1 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Research Focus:host-pathogen & immune response· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

U. Martin· 6 shared S. Ciesek· 3 shared A. Richter· 2 shared C. Drosten· 2 shared C. Goffinet· 2 shared D. Bojkova· 2 shared D. Niemeyer· 2 shared D. Roth· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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6 shared papersMicrobiology

U. Martin

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Structure-function relationships of mucociliary clearance in human and rat airways

D. Roth, A. T. Sahin, F. Ling, N. Tepho, C. Senger, E. Quiroz, B. Calvert, A. van der Does, T. G. Güney, S. Glasl, A. van Schadewijk, L. von Schledorn, R. Olmer, E. Kanso, J. C. Nawroth, A. L. Ryan

The paper compares mucociliary clearance in human and rat airways, finding species-specific structural differences that affect clearance effectiveness and identifying limitations of lab-grown cultures.

bioRxiv · Dec 24, 2023Biophysics

NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner

F. H. Waqas, M. Shehata, W. A. M. Elgaher, A. Lacour, N. Kurmasheva, F. Begnini, A. E. K. E. Kiib, J. Dahlmann, C. Chen, T. B. Poulsen, S. Merkert, U. Martin, R. Olmer, D. Olagnier, A. Hirsch, , F. Pessler

This paper shows NRF2 activators inhibit influenza A virus by blocking nuclear export of viral RNPs, independent of NRF2 signaling, through interaction with XPO1 and KEAP1.

bioRxiv · Jun 11, 2023Microbiology

Primary Ciliary Dyskinesia patient specific hiPSC-derived airway epithelium in Air Liquid Interface culture recapitulates disease specific phenotypes in vitro

L. von Schledorn, D. P. Martin, N. Cleve, J. Zoellner, D. Roth, B. O. Staar, J. Hegermann, F. Ringshausen, J. C. Nawroth, U. Martin, R. Olmer

The paper develops an in vitro model of PCD using hiPSC-derived airway epithelium that recapitulates disease-specific phenotypes.

bioRxiv · Apr 25, 2023 · PreprintBioengineering

Pharmacological inhibition of bromodomain and extra-terminal proteins induces NRF-2-mediated inhibition of SARS-CoV-2 replication and is subject to viral antagonism

B. Mhlekude, D. Postmus, J. Weiner, S. Stenzel, F. J. Zapatero-Belinchon, R. Olmer, J. Jansen, A. Richter, J. Heinze, N. Heinemann, B. Muhlemann, S. Schroeder, T. C. Jones, M. A. Muller, C. Drosten, , C. Goffinet

This study shows JQ-1 inhibits SARS-CoV-2 replication via NRF-2 activation but is counteracted by viral antagonism, leading to transient antiviral effects.

bioRxiv · Sep 22, 2022 · PreprintMicrobiology

Omicron-induced interferon signalling prevents influenza A virus infection

D. Bojkova, M. Bechtel, T. Rothenburger, J. D. Kandler, L. Hayes, R. Olmer, U. Martin, D. Jonigk, S. Ciesek, M. N. Wass, M. Michaelis, J. Cinatl

This study shows Omicron variants induce interferon responses in human cells, protecting against influenza A virus super-infection, while Delta does not.

bioRxiv · Sep 6, 2022 · PreprintMicrobiology

Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform

D. Bojkova, P. Reus, L. Panosch, M. Bechtel, T. Rothenburger, J. Kandler, A. Pfeiffer, J. U. Wagner, M. Shumliakivska, S. Dimmeler, R. Olmer, U. Martin, F. Vondran, T. Toptan, F. Rothweiler, , J. Cinatl

This study develops a phenotypic screening platform using caspase 3/7 activity to identify antiviral compounds against SARS-CoV-2, including novel candidates and combinations.

bioRxiv · Jul 17, 2022Pharmacology & Toxicology

Post-entry, spike-dependent replication advantage of B.1.1.7 and B.1.617.2 over B.1 SARS-CoV-2 in an ACE2-deficient human lung cell line

D. Niemeyer, S. Schroeder, K. Friedmann, F. Weege, J. Trimpert, A. Richter, S. Stenzel, J. Jansen, J. Emanuel, J. Kazmierski, F. Pott, L. M. Jeworowski, R. Olmer, M.-C. Jaboreck, B. Tenner, , C. Drosten

The paper shows that B.1.1.7 and B.1.617.2 SARS-CoV-2 variants have a replication advantage over B.1 in ACE2-deficient lung cells, suggesting reliance on alternative cellular factors.

bioRxiv · Oct 20, 2021 · PreprintMicrobiology