Author

A. L. Ryan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Assay:bulk RNA-seq· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 3 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

B. A. Calvert· 3 shared B. Zhou· 3 shared J. C. Nawroth· 3 shared W. D. Wallace· 3 shared A. van Schadewijk· 2 shared C. N. Marconett· 2 shared C. N. Senger· 2 shared D. Roth· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCell Biology

B. A. Calvert

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Structure-function relationships of mucociliary clearance in human and rat airways

D. Roth, A. T. Sahin, F. Ling, N. Tepho, C. Senger, E. Quiroz, B. Calvert, A. van der Does, T. G. Güney, S. Glasl, A. van Schadewijk, L. von Schledorn, R. Olmer, E. Kanso, J. C. Nawroth, A. L. Ryan

The paper compares mucociliary clearance in human and rat airways, finding species-specific structural differences that affect clearance effectiveness and identifying limitations of lab-grown cultures.

bioRxiv · Dec 24, 2023Biophysics

RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis

E. J. Quiroz, S. Kim, L. K. Gautam, Z. Borok, C. Kintner, A. L. Ryan

The paper identifies RBL2 as a repressor of Multicilin's transcriptional activity, showing it inhibits multiciliogenesis in airway epithelial cells.

bioRxiv · Aug 4, 2023Cell Biology

Targeting Fibroblast-Endothelial Interactions in LAM Pathogenesis: 3D Spheroid and Spatial Transcriptomic Insights for Therapeutic Innovation

S. Koc-Gunel, E. C. Liu, L. K. Gautam, B. A. Calvert, S. Murthy, N. C. Harriott, J. C. Nawroth, B. Zhou, V. P. Krymskaya, A. L. Ryan

The paper uses 3D spheroids and spatial transcriptomics to identify LAMFs and LECs as key contributors to LAM, with bFGF and VEGF-A as potential therapeutic targets.

bioRxiv · Jun 12, 2023 · PreprintCell Biology

Alveolar epithelial type 1 cells serve as a cell of origin for lung adenocarcinoma with distinct molecular and phenotypic presentation

M. Yang, H. Shen, P. Flodby, M. Koss, R. Bassiouni, Y. Liu, T. Jashashvilli, T. R. Stueve, D. J. Mullen, A. L. Ryan, J. Carpten, A. Castaldi, W. D. Wallace, B. Zhou, MD, Z. Borok, C. N. Marconett

This study identifies alveolar epithelial type 1 cells as a potential cell of origin for lung adenocarcinoma, showing distinct molecular and histological features based on cell of origin.

bioRxiv · Oct 29, 2022 · PreprintCancer Biology

Neutrophil-epithelial interactions augment infectivity and pro-inflammatory responses to SARS-CoV-2 infection

B. A. Calvert, E. J. Quiroz, Z. Lorenzana, N. Doan, S. Kim, C. N. Senger, W. D. Wallace, M. Salomon, J. Henley, A. L. Ryan

This study shows that neutrophil-epithelial interactions enhance SARS-CoV-2 infectivity and pro-inflammatory responses in airway epithelium.

bioRxiv · Aug 9, 2021 · PreprintCell Biology

Breathing on Chip: Dynamic flow and stretch tune cellular composition and accelerate mucociliary maturation of airway epithelium in vitro

J. C. Nawroth, D. Roth, A. van Schadewijk, A. Ravi, T. I. Maulana, C. N. Senger, S. van Riet, D. K. Ninaber, D. Kraft, P. S. Hiemstra, A. L. Ryan, A. M. van der Does

This study shows that applying airflow and stretch to airway epithelial cultures on a chip accelerates mucociliary maturation and alters cellular composition to better mimic airway biology.

bioRxiv · May 7, 2021 · PreprintCell Biology

Development of novel in vitro human alveolar epithelial cell models to study distal lung biology and disease

E. Tran, T. Shi, X. Li, A. Y. Chowdhury, D. Jiang, Y. Liu, H. Wang, C. Yan, W. D. Wallace, R. Lu, A. L. Ryan, C. N. Marconett, B. Zhou, Z. Borok, I. A. Offringa

The paper develops novel immortalized human alveolar epithelial cell lines that can form organoids and exhibit lineage memory, offering a new in vitro model for distal lung biology and disease.

bioRxiv · Dec 25, 2020 · PreprintCell Biology

A molecular atlas of proximal airway identifies subsets of known airway cell types revealing details of the unique molecular pathogenesis of Cystic Fibrosis

G. Carraro, J. Langerman, S. Sabri, Z. Lorenzana, A. Purkayastha, B. Konda, C. J. Aros, B. A. Calvert, A. Szymaniak, E. Wilson, M. Mulligan, P. Bhatt, P. Vijayaraj, C. Yao, D. W. Shia, , B. N. Gomperts

The paper uses single-cell transcriptomics to analyze proximal airway epithelium in CF and healthy donors, identifying molecular changes linked to CF pathogenesis.

bioRxiv · May 1, 2020Cell Biology