A. Prabhakar

Depletion of Protein Phosphatase 1 Results in Persistent Activation of the Integrated Stress Response and Age-Associated Exacerbation of Pulmonary Veno-Occlusive Disease

This study shows that older rats develop more severe PVOD after MMC treatment due to reduced protein phosphatase 1, leading to prolonged ISR activation, and that blocking the PKR-ISR pathway reduces PVOD symptoms.

Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response

This study shows that inhibiting the integrated stress response (ISR) or PKR reduces vascular remodeling in PVOD models, suggesting potential therapeutic strategies.

Multiplexed fluorescence and scatter detection with single cell resolution using on-chip fiber optics for droplet microfluidic applications

The paper introduces OptiDrop, a platform that enables multi-parametric optical sensing of microfluidic droplets with single-cell resolution using on-chip fiber optics.

New Features Surrounding the Cdc42-Ste20 Module that Regulates MAP Kinase Signaling in Yeast

This study identifies new regulatory features of the Cdc42-Ste20 module in yeast MAPK signaling, including Ste20p turnover and a Ste20p-independent pathway branch.

Mechanisms that ensure speed and fidelity in eukaryotic translation termination

The paper uses single-molecule fluorescence assays to study eukaryotic translation termination dynamics in yeast, revealing a conserved multi-step process involving eRF1 and eRF3.

Partial spontaneous intersubunit rotations in actively translating ribosomes

This study uses high-speed single-molecule TIRF microscopy to show that actively translating ribosomes undergo partial spontaneous rotations between three states, bridging conflicting models of ribosome dynamics.

Spatiotemporal Control of Pathway Sensors and Cross-Pathway Feedback Regulate a Cell Differentiation MAPK Pathway in Yeast

The paper shows that temporal and spatial regulation of pathway sensors and cross-pathway feedback control the fMAPK pathway in yeast.

Regulation of Bud Emergence by a MAPK Pathway

This study shows the MAPK pathway regulates bud emergence in yeast under nutrient-limiting conditions by modulating Cdc42p activity and polarity targets.

Proteins That Interact with the Mucin-Type Glycoprotein Msb2p Include Regulators of the Actin Cytoskeleton

The paper identifies proteins interacting with the yeast mucin Msb2p, revealing its role in connecting signaling to actin cytoskeleton regulation and other cellular processes.

eIF5B gates the transition from translation initiation to elongation

The paper investigates how eIF5B facilitates the transition from translation initiation to elongation in yeast using single-molecule fluorescence microscopy.