C. Bertozzi

Bioorthogonal metabolic labeling of the virulence factor phenolic glycolipid in mycobacteria

The paper develops a method to image phenolic glycolipid (PGL) in mycobacteria using bioorthogonal metabolic labeling and demonstrates its application in studying PGL dynamics.

The microenvironment dictates glycocalyx construction and immune surveillance

This study shows that the physical properties of the microenvironment influence glycocalyx composition and immune surveillance in vitro using physiologically relevant models.

Butyrate differentiates permissiveness to Clostridioides difficile infection and influences growth of diverse C. difficile isolates

This study shows butyrate reduces C. difficile fitness in mice and humans, and inhibits growth of diverse C. difficile isolates, suggesting dietary interventions could help prevent CDI.

Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis bioaerosols

This study develops a device to capture and detect live Mycobacterium tuberculosis in bioaerosols, showing high detection rates and suggesting aerosol sources differ from sputum.

Zika Virus Infection Prevents Host mRNA Nuclear Export by Disrupting UPF1 Function

This study shows ZIKV infection disrupts UPF1 function, leading to nuclear mRNA accumulation and impaired neural progenitor cell function.

Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection

This study identifies 309 host proteins interacting with SARS-CoV-2 RNA during infection and reveals their roles in virus-induced cell death and mitochondrial dysfunction.

Spreading of a mycobacterial cell surface lipid into host epithelial membranes promotes infectivity

This study shows that PDIM from mycobacteria spreads into host epithelial membranes, inhibiting TLR activation and enhancing infectivity, with statins reducing this spread and offering protection.