M. P. Rout

This study identifies mechanisms enabling nanobodies to bind antigens with high affinity and stability, revealing a conserved region critical for their function and suggesting strategies for their optimization.

The paper shows that nanobodies against ancestral SARS-CoV-2 spike protein remain effective against recent variants, including omicron sublineages and emerging XBB/BQ.1.1 variants.

The paper investigates the dynamic behavior of the nuclear pore complex permeability barrier in yeast, showing it functions as a dynamic polymer brush rather than a phase-separated condensate.

This study identifies distinct roles for three Mex67 paralogs in trypanosome RNA processing and export, showing non-redundant functions in mRNA export and ribosome biogenesis.

This study identifies Nup170's role in subtelomeric gene silencing by regulating PCNA levels through the Ctf18-RFC complex and Mlp1/Mlp2-dependent NPC subpopulations.

This paper presents a large repertoire of high-affinity nanobodies against SARS-CoV-2 Spike protein with potent neutralization properties and resistance to viral variants.

The paper shows Heh2/Man1 interacts with NPC components in yeast and suggests it senses NPC assembly state for quality control and segregation.

This study maps the human nuclear cap-binding complex interactome using affinity proteomics to clarify the composition and interactions of NCBP1, NCBP2, and NCBP3-related macromolecular assemblies.

The paper evaluates three surface-based methods for characterizing protein-protein interactions involving intrinsically disordered proteins, revealing previously overlooked mass transport limitations and additional binding modes.