Author

C. F. Basler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2

Frequent Co-Authors

C. G. Williams· 4 shared A. S. Jureka· 3 shared G. K. Amarasinghe· 3 shared R. A. Davey· 3 shared D. W. Leung· 2 shared J. A. Silvas· 2 shared J. Sweeney-Gibbons· 2 shared M. L. Gross· 2 shared

Activity by Year

2019-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

C. G. Williams

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics

R. J. Carlson, J. J. Patten, G. Stefanakis, B. Y. Soong, A. Radhakrishnan, A. Singh, N. Thakur, G. K. Amarasinghe, N. Hacohen, C. F. Basler, D. Leung, C. Uhler, R. A. Davey, P. C. Blainey

This study uses single-cell image-based CRISPR screens to identify host factors regulating Ebola virus infection, revealing new therapeutic targets like UQCRB and STRAP.

bioRxiv · Apr 6, 2024 · PreprintMicrobiology

The Role of Ebola Virus VP24 Nuclear Trafficking Signals in Infectious Particle Production

O. A. Vogel, E. Nafziger, A. Sharma, H. A. Pasolli, R. A. Davey, C. F. Basler

This study demonstrates that Ebola virus VP24 undergoes nuclear trafficking via IMPA and its nuclear export signal (NES) is critical for nucleocapsid formation and infectivity.

bioRxiv · Mar 13, 2024 · PreprintMicrobiology

Marburg and Ebola virus mRNA 3 untranslated regions contain negative regulators of translation that are modulated by ADAR1 editing

S. Khadka, C. G. Williams, J. Sweeney-Gibbons, C. F. Basler

This study identifies ADAR1-mediated editing of filovirus 3UTRs as negative regulators of translation, showing that editing or deletion enhances translation and modulates immune responses.

bioRxiv · Apr 21, 2021Microbiology

Pulsed broad-spectrum UV light effectively inactivates SARS-CoV-2 on multiple surfaces

A. S. Jureka, C. G. Williams, C. F. Basler

This study shows that pulsed broad-spectrum UV light inactivates SARS-CoV-2 on plastic, glass, stainless steel, and N95 respirators at specific UV doses.

bioRxiv · Feb 12, 2021Microbiology

Characterization of SARS-CoV-2 N protein reveals multiple functional consequences of the C-terminal domain

C. Wu, A. J. Qavi, A. Hachim, N. Kavian, A. R. Cole, A. B. Moyle, N. D. Wagner, J. Sweeney-Gibbons, H. W. Rohrs, M. L. Gross, J. S. M. Peiris, C. F. Basler, C. W. Farnsworth, S. A. Valkenburg, G. K. Amarasinghe, D. W. Leung

This study characterizes the SARS-CoV-2 N protein, identifying domain-specific functions and highlighting the C-terminal domain's immunogenicity for diagnostic applications.

bioRxiv · Nov 30, 2020Biochemistry

Inhibitors of VPS34 and lipid metabolism suppress SARS-CoV-2 replication

J. A. Silvas, A. S. Jureka, A. M. Nicolini, S. A. Chvatal, C. F. Basler

The paper tests inhibitors of VPS34 and lipid metabolism for their ability to suppress SARS-CoV-2 replication in cell lines.

bioRxiv · Jul 18, 2020Microbiology

Propagation, inactivation, and safety testing of SARS-CoV-2

A. S. Jureka, J. A. Silvas, C. F. Basler

The paper describes methods for propagating SARS-CoV-2 in cell lines and testing its infectivity, along with validated inactivation techniques for safe study of viral components.

Viruses · Jun 6, 2020Peer-reviewedMicrobiology

Non-canonical proline-tyrosine interactions with multiple host proteins regulate Ebola virus infection

J. Batra, M. Anantpadma, G. I. Small, O. Shtanko, M. Zhang, D. Liu, C. G. Williams, N. Biedenkopf, S. Becker, M. L. Gross, D. W. Leung, R. A. Davey, G. K. Amarasinghe, N. J. Krogan, C. F. Basler

This study identifies non-canonical proline-tyrosine interactions in the Ebola virus VP30 protein that regulate viral replication by interacting with multiple host proteins.

bioRxiv · May 19, 2020Microbiology

Marburg and Ebola virus infections elicit a complex, muted inflammatory state in bats

A. D. Jayaprakash, A. J. Ronk, A. N. Prasad, M. F. Covington, K. R. Stein, T. M. Schwarz, S. Hekmaty, K. A. Fenton, T. W. Geisbert, C. F. Basler, A. Bukreyev, R. Sachidanandam

This study investigates how Marburg and Ebola viruses elicit a complex, muted inflammatory response in bats, revealing mechanisms that may explain their non-pathogenicity in these animals.

bioRxiv · Apr 13, 2020Microbiology

Impact of Mengla virus proteins on human and bat innate immune pathways

C. G. Williams, J. S. Gibbons, T. R. Kieffer, P. Luthra, M. R. Edwards, C. F. Basler

This paper compares MLAV viral proteins to EBOV and MARV homologs in their ability to modulate innate immune pathways in human and bat cells, identifying similarities and differences in IFN suppression mechanisms.

bioRxiv · Jul 1, 2019Microbiology