Author

A. Bhutkar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

T. Jacks· 4 shared J. M. Schenkel· 2 shared S. Naranjo· 2 shared A. Babic· 1 shared A. C. Koong· 1 shared A. Dias Costa· 1 shared A. F. Hezel· 1 shared A. Ghosh· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersCancer Biology

T. Jacks

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform

S. Naranjo, C. M. Cabana, L. M. LaFave, P. M. Westcott, R. Romero, A. Ghosh, L. Z. Liao, J. M. Schenkel, I. Del Priore, A. Bhutkar, D. Yang, T. Jacks

This study develops a reliable alveolar type 2 organoid platform to model diverse genetic subtypes of lung adenocarcinoma in vitro and in vivo.

bioRxiv · Dec 7, 2021 · PreprintCancer Biology

Mismatch repair deficiency is not sufficient to increase tumor immunogenicity

P. M. K. Westcott, F. Muyas, O. Smith, H. Hauck, N. J. Sacks, Z. A. Ely, A. M. Jaeger, W. M. Rideout, A. Bhutkar, D. Zhang, M. C. Beytagh, D. A. Canner, R. T. Bronson, S. Naranjo, A. Jin, , T. Jacks

This study shows that MMRd in mouse tumor models does not increase immunogenicity or ICB response, due to intratumoral heterogeneity.

bioRxiv · Aug 24, 2021 · PreprintCancer Biology

An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis

M. M. Wilson, C. Callens, M. Le Gallo, S. Mironov, Q. Ding, A. Salamagnon, T. Chavarria, A. Peasah, A. Bhutkar, S. Martin, F. Godey, P. Tas, A. Jetten, J. E. Visvader, R. Weinberg, , V. Guen

This study identifies an EMT-primary cilium-GLIS2 signaling axis that regulates mammary stem cell properties and claudin-low breast tumorigenesis.

bioRxiv · Dec 29, 2020Cell Biology

Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma

K. M. Chung, J. Singh, L. Lawres, K. J. Dorans, C. Garcia, D. B. Burkhardt, R. Robbins, A. Bhutkar, R. Cardone, X. Zhao, A. Babic, S. A. Vayrynen, A. Dias Costa, J. A. Nowak, D. T. Chang, , M. D. Muzumdar

This study shows obesity accelerates pancreatic cancer by altering the tumor microenvironment, with reversible effects through weight loss.

bioRxiv · Sep 26, 2019Cancer Biology

Longitudinal single cell profiling of regulatory T cells identifies IL-33 as a driver of tumor immunosuppression

A. Li, R. H. Herbst, D. Canner, J. M. Schenkel, O. C. Smith, J. Y. Kim, M. Hillman, A. Bhutkar, M. S. Cuoco, C. G. Rappazzo, P. Rogers, C. Q. Dang, O. Rozenblatt-Rosen, L. Cong, M. Birnbaum, , T. Jacks

The paper identifies IL-33 as a driver of tumor immunosuppression by analyzing longitudinal single-cell RNA-Seq data of regulatory T cells in a mouse model of lung adenocarcinoma.

bioRxiv · Jan 6, 2019 · PreprintCancer Biology