Author

J. Lowe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:structural biology· 2 Organism:Arabidopsis· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

A. Gonzalez Llamazares· 2 shared D. Kureisaite-Ciziene· 2 shared R. Salzer· 2 shared A. Albecka· 1 shared A. Dimond· 1 shared A. Feytout· 1 shared A. G. Fisher· 1 shared A. Garcia-Sanchez· 1 shared

Activity by Year

2016-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersImmunology

A. Gonzalez Llamazares

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Characterisation of the Ubiquitin-ESCRT pathway in Asgard archaea sheds new light on origins of membrane trafficking in eukaryotes

T. Hatano, S. Palani, D. Papatziamou, R. Salzer, D. Souza, D. Tamarit, M. Makwana, A. Potter, A. Haig, W. Xu, D. Bellini, D. Townsend, D. Rochester, H. Hussain, T. Ettema, , M. Balasubramanian

This study characterizes the ubiquitin-ESCRT pathway in Asgard archaea, showing its pre-eukaryotic origin and evolutionary path through gene duplication.

bioRxiv · Aug 17, 2021Cell Biology

Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice

R. Salzer, J. J. Clark, M. Vaysburd, V. T. Chang, A. Albecka, L. Kiss, P. Sharma, A. Gonzalez Llamazares, A. Kipar, J. A. Hiscox, A. Owen, A. R. Aricescu, J. P. Stewart, L. C. James, J. Lowe

This paper demonstrates that a multimerised SARS-CoV-2 RBD vaccine using a stable scaffold provides enhanced antibody responses and complete protection in mice.

bioRxiv · May 18, 2021Immunology

ATP dependent DNA transport within cohesin: Scc2 clamps DNA on top of engaged heads while Scc3 promotes entrapment within the SMC-kleisin ring

J. E. Collier, B.-G. Lee, M. Brunet-Roig, S. Yatskevich, N. J. Petela, J. Metson, M. Voulgaris, A. Gonzalez Llamazares, J. Lowe, K. A. Nasmyth

The paper demonstrates that Scc2 clamps DNA in cohesin's E-S/E-K compartments while Scc3 facilitates DNA entrapment within the SMC-kleisin ring during DNA loop extrusion.

bioRxiv · Jun 3, 2020 · PreprintBiochemistry

Systematic identification of factors bound to isolated metaphase ESC chromosomes reveals a role for chromatin repressors in compaction

D. Djeghloul, A.-C. Kohler, B. Patel, H. Kramer, N. Veland, C. Whilding, A. Dimond, J. Elliott, A. Feytout, T. A. M. Bharat, A. K. Tarafder, J. Lowe, B. L. Ng, Y. Guo, K. Brown, , A. G. Fisher

The paper identifies proteins bound to metaphase ESC chromosomes and shows chromatin repressors are involved in maintaining chromosome compaction.

bioRxiv · Aug 28, 2019Cell Biology

Structural analysis of the interaction between the bacterial cell division proteins FtsQ and FtsB

D. Kureisaite-Ciziene, A. Varadajan, S. H. McLaughlin, M. Glas, A. M. Silva, R. Luirink, C. Mueller, T. den Blaauwen, T. N. Grossmann, J. Luirink, J. Lowe

This study investigates the interaction between FtsQ and FtsB in E. coli, revealing key residues and structural details critical for cell division.

bioRxiv · Jul 4, 2018Microbiology

A polymerisation-associated conformational switch in FtsZ that enables treadmilling

J. M. Wagstaff, M. Tsim, M. A. Oliva, A. Garcia-Sanchez, D. Kureisaite-Ciziene, J. M. Andreu, J. Lowe

This study identifies a conformational switch in FtsZ that enables treadmilling and cooperative filament assembly during bacterial cell division.

bioRxiv · Dec 13, 2016Microbiology