J. Morton

Meta-analysis of the human gut microbiome uncovers shared and distinct microbial signatures between diseases

This study performs a meta-analysis of gut microbiome data across 11 diseases, identifying shared and distinct microbial signatures using machine learning and differential abundance analysis.

Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity

The paper shows that ionizing radiation enhances immunotherapy in pancreatic cancer by increasing tissue-resident NK cells that support CD8 T cell activity through cDC1-dependent mechanisms.

Hexavalent Sperm-Binding IgG Antibody Released from Self-Dissolving Vaginal Film Enables Potent, On-Demand Non-Hormonal Female Contraception

This paper develops a non-hormonal contraceptive method using a hexavalent sperm-binding antibody delivered via a dissolving vaginal film, showing potent sperm inhibition in sheep.

The primary donor of far-red Photosystem II: ChlD1 or PD2?

The paper confirms the 726 nm chlorophyll as the primary donor in far-red PSII from Chroococcidiopsis thermalis and suggests PD2 is as likely as ChlD1 based on spectroscopic and modeling data.

BRD4-mediated repression of p53 is a target for combination therapy in AML

This study shows that combining MDM2 inhibitors and BET inhibitors synergistically kills AML cells by enhancing p53 activation through BRD4's repressive function.

Red Sea SAR11 and Prochlorococcus Single-cell Genomes Reflect Globally Distributed Pangenomes

The paper analyzes single-cell genomes from Red Sea SAR11 and Prochlorococcus to assess if they harbor unique gene content, finding that most are cosmopolitan but some are regionally enriched.