Author

J. Olejnik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

E. Muhlberger· 5 shared A. J. Hume· 3 shared D. N. Kotton· 2 shared E. Bullitt· 2 shared E. L. Suder· 2 shared J. Berrigan· 2 shared J. Huang· 2 shared S. Gummuluru· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersCell Biology

E. Muhlberger

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells

C. Zhao, W. Wang, Y. Bai, G. Amonkar, H. Mou, J. Olejnik, A. J. Hume, E. Muhlberger, Y. Fang, J. Que, R. Fearns, X. Ai, P. H. Lerou

The paper shows that age-related STAT3 signaling impairment in neonatal bronchial epithelial cells increases RSV infection severity, while SARS-CoV-2 is unaffected by age.

bioRxiv · Sep 20, 2023 · PreprintCell Biology

CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses

S. Jalloh, J. Olejnik, J. Berrigan, A. Nisa, E. L. Suder, H. Akiyama, M. Lei, S. Tyagi, Y. Bushkin, E. Muhlberger, S. Gummuluru

This study shows CD169 enables ACE2-independent SARS-CoV-2 entry in macrophages, leading to restricted viral replication and pro-inflammatory cytokine production.

bioRxiv · Mar 29, 2022Immunology

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV2 at the immune-epithelial interface

J. Leon, D. A. Michelson, J. Olejnik, K. Chowdhary, H. S. Oh, A. J. Hume, S. Galvan-Pena, Y. Zhu, F. Chen, B. Vijaykumar, L. Yang, E. Crestani, L. M. Yonker, D. M. Knipe, E. Muhlberger, C. Benoist

The paper investigates SARS-CoV2-induced inflammatory responses in monocytes using in vitro co-cultures, identifying a virus-specific gene cluster distinct from other viruses.

bioRxiv · Sep 29, 2021 · PreprintImmunology

Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses

A. J. Hume, B. Heiden, J. Olejnik, E. L. Suder, S. Ross, W. A. Scoon, E. Bullitt, M. Ericsson, M. R. White, J. Turcinovic, T. T. N. Thao, R. M. Hekman, J. E. Kaserman, J. Huang, K. Alysandratos, , E. Mühlberger

This study uses recombinant Lloviu virus to investigate replication mechanisms and host interactions of an uncultured filovirus related to Ebola.

bioRxiv · Aug 2, 2021 · PreprintMicrobiology

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

R. Wang, A. Hume, M. L. Beermann, C. Simone-Roach, J. Lindstrom-Vautrin, J. Le Suer, J. Huang, J. Olejnik, C. Villacorta-Martin, E. Bullitt, A. Hinds, M. Ghaedi, R. Werder, K. Abo, A. Wilson, , F. J. Hawkins

This study uses iPSC-derived airway cells to model SARS-CoV-2 infection, showing multiciliated cells as primary targets and demonstrating antiviral responses to remdesivir and camostat methylate.

bioRxiv · Jul 6, 2021Cell Biology

CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2

R. Amraei, M. Napoleon, W. Yin, J. Berrigan, E. Suder, G. Zhao, J. Olejnik, K. Chandler, C. Xia, S. Gummuluru, E. Muhlberger, V. Chitalia, C. Costello, N. Rahimi

This study identifies CD209L/L-SIGN and CD209/DC-SIGN as alternative receptors for SARS-CoV-2, capable of mediating virus entry into human cells, particularly in tissues with low ACE2 expression.

bioRxiv · Jun 22, 2020 · PreprintCell Biology