C. Tong

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

Evaluation of a BE-inactivated whole virus preparation using an encephalomyocarditis virus strain that was isolated from fatal infection in orangutans.

The paper evaluates a BE-inactivated EMCV-3 virus as a potential vaccine candidate, showing strong neutralizing titers in mice.

Insulin determines the effects of TGF-beta on HNF4alpha transcription and epithelial-to-mesenchymal transition in hepatocytes

This study shows insulin prevents TGF-beta-induced EMT in hepatocytes by inhibiting SMAD2/3 binding to C/EBP and SNAI1 promoters, maintaining HNF4 expression.

Myosin-Binding Protein C Stabilizes, But Is Not the Sole Determinant of SRX Myosin in Cardiac Muscle

This study investigates the role of MyBP-C in stabilizing the SRX myosin state in cardiac muscle using transgenic mice and super-resolution microscopy, finding that MyBP-C's N-terminal region is critical for maintaining SRX along the thick filament.

Convergent genomic signatures of adaptation to an extreme environment in cyprinoid fishes

The paper identifies common genomic changes in two cyprinoid fish species adapted to extreme saline and alkaline environments, revealing convergent selection patterns and functional gene categories.

Constitutive, calcium-independent endoplasmic reticulum-plasma membrane contact site oscillations and its implications in store-operated calcium entry

This study investigates calcium-independent ER-PM contact site oscillations in RBL mast cells and their role in SOCE, showing PI(4)P dependency and the importance of reversible contact sites for calcium oscillations.

Single Cell Raman-Deuterium Isotope Probing for Drug Resistance of Elizabethkingia spp.

This study uses single cell Raman-DIP to rapidly determine antimicrobial susceptibility of Elizabethkingia spp. and confirms minocycline and levofloxacin as first-line treatments.

Genomic signatures of recent convergent transitions to social life in spiders

This study identifies genomic changes associated with the transition to social life in spiders by comparing 22 species, finding shifts in selection and elevated molecular evolution rates in social species.

Genomic signature of shifts in selection and alkaline adaptation in highland fish

This study compares 15 fish species to identify genomic signatures of alkaline adaptation in both highland and lowland fish, finding consistent patterns of accelerated evolution and positive selection in shared genes.

Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment

The paper characterizes antibiotic resistance genes and opportunistic pathogens in a hospital environment using genomic sequencing and identifies multidrug-resistant strains persisting for over 8 years.

Comparative genomics identifies putative signatures of sociality in spiders

This study identifies genomic signatures of sociality in spiders by comparing social and solitary species, finding expanded gene families and accelerated evolution in social species.

Collective membrane dynamics emerging from curvature-dependent spatial coupling

The paper shows membrane curvature drives collective dynamics of cortical proteins through mechanochemical feedback, influencing wave propagation and spatiotemporal patterns.