E. Alsberg

In situ cell condensation-based cartilage tissue engineering via immediately implantable high-density stem cell core and rapidly degradable shell microgels

This paper develops core/shell microgels for in situ cartilage tissue engineering, enabling immediate implantation and spontaneous fusion of cell condensates without prior in vitro culture.

Cyr61 delivery promotes angiogenesis during bone fracture repair

This study shows that Cyr61 delivery enhances angiogenesis during bone fracture repair, particularly in fractures with stable fixation, and may have therapeutic potential for poor vascularization.

A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis

This paper introduces a microarray 3D bioprinting platform with pillar and perfusion plates for high-throughput human organoid culture and analysis.

Optimizing bioink composition for human chondrocyte expression of lubricin

This study identifies an optimal bioink composition for enhancing lubricin expression in human chondrocytes using a high-throughput reporter system and 3D bioprinting.

Long-term functional regeneration of radiation damaged salivary glands through delivery of a neurogenic hydrogel

This study shows that a neurogenic hydrogel can regenerate radiation-damaged salivary glands in mice, restoring saliva production over three months.

4D Cell-Condensate Bioprinting

This paper introduces a 4D bioprinting method to create shape-morphing cell condensate bilayers with predefined geometries, demonstrating its use in forming complex shapes like 'C' and helix-shaped cartilage-like tissues from hMSCs.

Stem cell-laden hydrogel bioink for generation of high resolution and fidelity engineered tissues with complex geometries

This study develops a stem cell-laden hydrogel bioink that enables high-resolution and fidelity 3D bioprinting of complex tissue structures.

Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration

This study shows that scaffold-free human mesenchymal stem cell tubes, with specific geometry and morphogen presentation, enhance endochondral bone regeneration in critical-sized femoral defects compared to loose hMSC sheets.

Living cell-only bioink and photocurable supporting medium for printing and generation of engineered tissues with complex geometries

This paper introduces a cell-only bioink and supporting medium for 3D printing and long-term culture of functional tissues without a biomaterial scaffold.

Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair

The paper demonstrates that engineered human mesenchymal stem cell condensations with dual BMP-2 and TGF-β1 promote functional healing of critical-sized femoral defects via endochondral ossification, with healing rate and extent dependent on in vivo mechanical environment.

Recapitulating bone development for tissue regeneration through engineered mesenchymal condensations and mechanical cues

This study shows that mechanical loading enhances bone regeneration through engineered mesenchymal condensations, mimicking endochondral ossification without heterotopic bone formation.