Author

T. Fabo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

L. I. Zon· 2 shared A. Thomas· 1 shared B. J. Abraham· 1 shared C. G. Ludwig· 1 shared C. K. Kaufman· 1 shared C. Wu· 1 shared D. Liu· 1 shared E. van Rooijen· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

L. I. Zon

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

SATB2 induction of a neural crest mesenchyme-like program drives invasion and drug resistance in melanoma

M. Fazio, E. van Rooijen, M. Dang, G. van de Hoek, J. Ablain, J. K. Mito, S. Yang, A. Thomas, J. Michael, T. Fabo, R. Modhurima, P. Pessina, C. K. Kaufman, Y. Zhou, R. M. White, L. I. Zon

This study shows SATB2 drives melanoma invasion and drug resistance by inducing a neural crest mesenchyme-like transcriptional program in zebrafish and human models.

bioRxiv · Nov 1, 2020Cancer Biology

CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts

M. L. Insco, B. J. Abraham, S. J. Dubbury, S. Dust, C. Wu, K. Y. Chen, D. Liu, C. G. Ludwig, S. Bellaousov, T. Fabo, T. Henriques, K. Adelman, M. Geyer, P. A. Sharp, R. A. Young, , L. I. Zon

This study identifies CDK13 mutations in melanoma, showing they lead to accumulation of truncated transcripts and poor survival, with a mechanism involving impaired ZC3H14 phosphorylation and PAXT complex recruitment.

bioRxiv · Nov 5, 2019Biophysics