K. Castillo

Loss of cell junctional components and matrix alterations drive cell desquamation and fibrotic changes in Idiopathic Pulmonary Fibrosis

The study identifies loss of cell junctions and matrix dysregulation as drivers of epithelial desquamation and fibrosis in IPF distal bronchioles.

High Throughput Screening with a Primary Human Mucociliary Airway Model Identifies a Small Molecule with Anti-SARS-CoV-2 Activity

This study uses a primary human stem cell-based airway model to screen 2100 compounds and identifies a small molecule effective against SARS-CoV-2 and its Omicron variant.

Discrete Multiwalled Carbon Nanotubes for Versatile Intracellular Transport of Functional Biomolecular Complexes

This study investigates the use of discrete multiwalled carbon nanotubes (dMWCNTs) as delivery vehicles for biomolecules, showing their ability to cross cell membranes and deliver peptides, mRNA, siRNA, and dsRNA.

Sex differences in central inflammatory pain sensitization are associated with differential expression of glycine receptors and GLP-1 at the spinal cord

This study compares sex differences in inflammatory pain sensitization in rats, finding that females show greater nociceptive threshold reduction and distinct glycine receptor and GLP-1 expression changes.

Calcium-driven regulation of voltage-sensing domains in BK channels

This study investigates how Ca2+ binding affects voltage-sensing domain activation in BK channels, showing coordinated interactions between Ca2+ sensors and VSDs.

Corals sustain growth but not skeletal density across the Florida Keys Reef Tract despite ongoing warming

This study examines coral growth and skeletal density across the Florida Keys Reef Tract over the past century, finding sustained extension rates but reduced skeletal density despite warming.