W. Choi

Combined Mek inhibition and Pparg activation Eradicates Muscle Invasive Bladder cancer in a Mouse Model of BBN-induced Carcinogenesis

This study shows that combining MEK inhibition and Pparg activation eradicates muscle-invasive bladder cancer in a mouse model by reversing tumor differentiation and inducing apoptosis.

Machine learning assisted health viability assay for mouse embryos with artificial confocal microscopy (ACM)

The paper develops a machine learning tool using artificial confocal microscopy to assess embryo viability by detecting nucleus features and classifying embryos into healthy/intermediate or sick categories.

Adaptive Optical Coherent Raman Imaging of Axons through Mouse Cranial Bone

This paper demonstrates label-free vibrational imaging of myelin in mouse brains through thick cranial bones using adaptive optics-enhanced coherent Raman scattering microscopy.

Functional Ultrasound Imaging of the Human Spinal Cord

This study uses functional ultrasound imaging to evaluate spinal cord hemodynamics in humans during epidural stimulation, revealing new insights into spinal circuitry and blood flow responses.

Label-free adaptive optics single-molecule localization microscopy for whole animals

This paper develops a label-free adaptive optics method for SMLM, enabling deep-tissue super-resolution imaging in whole animals by correcting tissue aberrations.

SdhA blocks disruption of the Legionella-containing vacuole by hijacking the OCRL phosphatase

The paper shows SdhA blocks OCRL phosphatase to maintain Legionella vacuole integrity, preventing bacterial degradation.

Decoding the role of CBLB for innate immune responses regulating systemic dissemination during Non-Tuberculous Mycobacteria infection

This study investigates the role of CBLB in innate immune responses during NTM infection, finding it essential for preventing dissemination under T-cell deficiency.

Components of the endocytic and recycling trafficking pathways interfere with the integrity of the Legionella-containing vacuole

The paper identifies host Rab GTPases and their effectors that disrupt vacuole integrity during Legionella pneumophila infection, showing their role in destabilizing the Legionella-containing vacuole.

A consensus molecular classification of muscle-invasive bladder cancer

The paper identifies six consensus molecular classes of muscle-invasive bladder cancer using transcriptomic data and classification systems, providing a framework for future biomarker validation.

Structure of the human lipid-sensitive cation channel TRPC3

The paper presents the structure of the human TRPC3 channel in a lipid-occupied closed state, revealing its unique architecture and lipid-binding sites.