C. Sen

Loss of cell junctional components and matrix alterations drive cell desquamation and fibrotic changes in Idiopathic Pulmonary Fibrosis

The study identifies loss of cell junctions and matrix dysregulation as drivers of epithelial desquamation and fibrosis in IPF distal bronchioles.

High Throughput Screening with a Primary Human Mucociliary Airway Model Identifies a Small Molecule with Anti-SARS-CoV-2 Activity

This study uses a primary human stem cell-based airway model to screen 2100 compounds and identifies a small molecule effective against SARS-CoV-2 and its Omicron variant.

Small cell lung cancer co-culture organoids provide insights into cancer cell survival after chemotherapy

This paper develops a 3D SCLC co-culture organoid model to study chemotherapy resistance and fibroblast interactions in relapsed SCLC.

Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response

This study identifies Hippo signaling pathway activation as an antiviral response to SARS-CoV-2 infection and shows pharmacological targeting of the pathway can reduce virus replication.

Antiviral Drug Screen of Kinase inhibitors Identifies Cellular Signaling Pathways Critical for SARS-CoV-2 Replication

This study screens kinase inhibitors to identify compounds that block SARS-CoV-2 replication by targeting key cellular signaling pathways.

Suppression of miR-155 attenuates lung cytokine storm induced by SARS-CoV-2 infection in human ACE2-transgenic mice

This study shows that suppressing miR-155 reduces lung inflammation and improves survival in SARS-CoV-2-infected human ACE2-transgenic mice.

Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stemcell-derived airway repair response

This study shows that cigarette smoke exposure increases SARS-CoV-2 infection severity in airway cultures by reducing interferon response and ABSC proliferation.

SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery

The paper develops a primary human lung epithelium infection model to study SARS-CoV-2 pathobiology and screen drugs for COVID-19.