B. Sahoo

Effects of protein G-quadruplex interactions on phase transitions and protein aggregation

This study shows Znf706 promotes protein aggregation but binds G-quadruplexes, which suppresses aggregation and affects mRNA levels.

How NINJ1 mediates plasma membrane rupture and why NINJ2 cannot

The paper identifies NINJ1 as an active mediator of plasma membrane rupture and explains why NINJ2 cannot, through structural and functional analysis of their filaments.

Probable omnigenic effect and evolutionary insights of aerobic adaptation allele OsNCED2T on qDTY12.1 effecting grain yield under reproductive stage drought stress in rice

The paper investigates the omnigenic effect of the OsNCED2T allele on qDTY12.1 grain yield under drought stress in rice and proposes a breeding model for drought tolerance.

Natural-abundance 17O NMR spectroscopy of magnetically aligned lipid nanodiscs

The paper uses natural-abundance 17O NMR to study water ordering in magnetically aligned lipid nanodiscs, combining RQCs and molecular dynamics simulations.

Degradation of Alzheimers Amyloid-beta by a Catalytically Inactive Insulin Degrading Enzyme

This study shows that a catalytically inactive insulin-degrading enzyme variant can degrade Alzheimer's amyloid-beta via a non-chaperone mechanism, with zinc binding inactivating its function.

Conformational Tuning of Amylin by Charged Styrene-maleic-acid Copolymers

This study shows that charged styrene-maleic-acid copolymers alter amylin aggregation and conformation, with SMAQA inhibiting fibrillation and SMAEA accelerating it.

Hsp70 inhibits aggregation of Islet amyloid polypeptide by binding to the heterogeneous prenucleation oligomers

This study shows Hsp70 inhibits IAPP aggregation by binding to oligomers, not monomers, preventing aberrant aggregation while preserving IDP function.

High Throughput Screening at the Membrane Interface Reveals New Inhibitors of Amyloid-β

This study identifies 5 small molecules that inhibit amyloid-β aggregation at the cell-membrane interface, which is relevant for Alzheimer's disease.

Apolipoprotein A-I Mimetic 4F Peptide Generates Amyloid Cytotoxins by Forming Hetero-oligomers with β-amyloid

The paper investigates how the 4F peptide interacts with β-amyloid to form toxic heteromers, reducing aggregation kinetics and increasing neurotoxicity.

High resolution structure of a partially folded insulin aggregation intermediate

The paper identifies a partially folded insulin intermediate involved in aggregation at acidic pH and describes its structural features that may promote oligomer formation.

Self-assembly of polymer-encased lipid nanodiscs and membrane protein reconstitution

This study optimizes coarse-graining models for polymer-encapsulated lipid nanodiscs to better study membrane protein structure and function.

Alzheimer’s Amyloid-Beta Intermediates Generated by Polymer-Nanodiscs

This study uses PMA-nanodiscs to study Aβ1-40 aggregation, showing they trap intermediates and reduce neurotoxicity of oligomers.

Cationic polymethacrylate-copolymer acts as an agonist for beta-amyloid and antagonist for amylin fibrillation

This study shows a cationic polymer promotes Aβ40 fibrillation and inhibits hIAPP aggregation through electrostatic interactions and structural restraint.

Zinc Boosts EGCG’s hIAPP Amyloid Inhibition Both in Solution and Membrane

This study shows that zinc enhances EGCG's ability to inhibit hIAPP amyloid aggregation both in solution and in the presence of lipid membranes.

ERBB2 and KRAS Alterations Mediate Response to EGFR Inhibitors in early stage Gallbladder Cancer

This study identifies ERBB2 and KRAS mutations in early-stage gallbladder cancer and shows their impact on response to EGFR inhibitors.

A fluorescence correlation spectrometer for measurements in cuvettes

This paper develops a fluorescence correlation spectrometer for single molecule measurements in cuvettes, achieving high counts per molecule and enabling protein unfolding studies with automatic titrators.