Author

K. Harcourt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

S. Clare· 5 shared C. Brandt· 4 shared A. T. Soderholm· 2 shared B. Moron· 2 shared B. S. Beresford-Jones· 2 shared C. Tolley· 2 shared G. Dougan· 2 shared G. Notley· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersImmunology

S. Clare

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Enterocloster clostridioformis induces host intestinal epithelial responses that protect against Salmonella infection

B. S. Beresford-Jones, S. Suyama, S. A. Clare, A. T. Soderholm, W. Xia, P. Sardar, K. Harcourt, T. D. Lawley, V. A. Pedicord

The paper identifies Enterocloster clostridioformis as a protective commensal bacterium that induces host intestinal epithelial responses to resist Salmonella infection.

bioRxiv · Jul 20, 2023 · PreprintMicrobiology

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

L. O. Randzavola, P. M. Mortimer, E. C. Garside, E. R. Dufficy, A. Schejtman, G. Roumelioti, L. Yu, M. Pardo, K. Spirohn, C. Tolley, C. Brandt, K. Harcourt, E. Nichols, M. Nahorski, G. Woods, , D. C. Thomas

This study identifies EROS as a chaperone essential for gp91phox maturation and P2X7 receptor function, revealing its role in immune responses and infection resistance.

bioRxiv · Sep 14, 2021Immunology

IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses

M. Clement, J. L. Forbester, M. Marsden, P. Sabberwal, D. Wellington, S. Dimonte, K. Harcourt, S. Clare, Z. Yin, L. Nobre, R. Antrobus, B. Jin, M. Chen, S. Makvandi-Nejad, J. A. Lindborg, , I. Humphreys

This study shows IFITM3 limits viral pathogenesis by regulating Nogo-B-mediated TLR responses and cytokine production in dendritic cells.

bioRxiv · Jul 23, 2021 · PreprintImmunology

An invariant Trypanosoma vivax vaccine antigen inducing protective immunity

D. Autheman, C. Crosnier, S. Clare, D. Goulding, C. Brandt, K. Harcourt, C. Tolley, F. Galaway, M. Khushu, H. Ong, A. Romero Ramirez, C. Duffy, A. Jackson, G. J. Wright

This study identifies an invariant Trypanosoma vivax antigen that induces protective immunity through vaccination and monoclonal antibodies.

Nature · May 26, 2021Peer-reviewedMicrobiology

Novel gut pathobionts confound results in a widely used mouse model of human inflammatory disease

S. C. Forster, S. Clare, B. S. Beresford-Jones, K. Harcourt, G. Notley, M. Stares, N. Kumar, A. T. Soderholm, A. Adoum, H. Wong, B. Moron, C. Brandt, G. Dougan, D. J. Adams, K. J. Maloy, , T. D. Lawley

The paper identifies two novel gut bacteria that influence disease variability in a mouse model of inflammatory bowel disease.

bioRxiv · Feb 9, 2021 · PreprintMicrobiology

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

L. Abeler-Dörner, A. Laing, A. Lorenc, D. S. Ushakov, S. Clare, A. Speak, M. A. Duque Correa, J. K. White, R. Ramirez-Solis, N. Saran, K. R. Bull, B. Moron, J. Iwasaki, P. R. Barton, S. Caetano, , Edmans

This study uses high-throughput phenotyping of knockout mice to identify genetic factors and structural patterns influencing immune variation.

bioRxiv · Jul 10, 2019Immunology