Author

D. Wellington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

T. Dong· 4 shared Z. Yin· 4 shared B. Jin· 2 shared D. Dong· 2 shared G. Liu· 2 shared I. Humphreys· 2 shared J. L. Forbester· 2 shared S. Makvandi-Nejad· 2 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersImmunology

T. Dong

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4 papers

Recent·Most cited

SARS-CoV-2 mutations affect proteasome processing to alter CD8+ T cell responses

D. Wellington, Z. Yin, Z. Yu, R. Heilig, S. Davis, R. Fischer, S. L. Felce, P. Hublitz, R. Beveridge, D. Dong, G. Liu, X. Yao, Y. Peng, B. M. M. Kessler, T. Dong

The paper investigates how mutations in flanking regions of SARS-CoV-2 nucleoprotein epitopes affect proteasome processing and CD8+ T cell responses, finding some mutations reduce responses while others enhance them.

bioRxiv · Apr 8, 2022 · PreprintImmunology

IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses

M. Clement, J. L. Forbester, M. Marsden, P. Sabberwal, D. Wellington, S. Dimonte, K. Harcourt, S. Clare, Z. Yin, L. Nobre, R. Antrobus, B. Jin, M. Chen, S. Makvandi-Nejad, J. A. Lindborg, , I. Humphreys

This study shows IFITM3 limits viral pathogenesis by regulating Nogo-B-mediated TLR responses and cytokine production in dendritic cells.

bioRxiv · Jul 23, 2021 · PreprintImmunology

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.

T. Dong, Y. Peng, A. J. Mentzer, G. Liu, X. Yao, Z. Yin, D. Dong, W. Dejnirattisai, L. Turtle, T. Rostron, K. Subramaniam, P. Thomson, P. Zhang, C. Dold, J. Ratcliff, , Lopez-C

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

bioRxiv · Jun 5, 2020Immunology

Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection

D. Wellington, Z. Yin, L. Zhang, J. L. Forbester, K. Kite, H. Laurenson-Schafer, S. Makvandi-Nejad, B. Jin, E. Bowes, K. Manoharan, D. Maldonado-Perez, C. Verrill, I. Humphreys, T. Dong

This study shows that low basal expression and slow induction of IFITM3 in immune cells increases their susceptibility to influenza A virus infection.

bioRxiv · Dec 20, 2019 · PreprintImmunology