Author

H. van Bakel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 10 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 8 Organism:human· 5 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Organism:virus· 2

Frequent Co-Authors

V. Simon· 6 shared A. Garcia-Sastre· 5 shared E. M. Sordillo· 3 shared F. Krammer· 3 shared J. Dutta· 3 shared R. Rathnasinghe· 3 shared T. Kehrer· 3 shared A. S. Gonzalez-Reiche· 2 shared

Activity by Year

2018-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMicrobiology

V. Simon

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Human influenza A virus H1N1 1 in marine mammals in California, 2019

M. Plancarte, G. Kovalenko, J. Baldassano, A. L. Ramirez, A. L. Ramirez, S. Carrillo, P. J. Duignan, I. G. Goodfellow, E. Bortz, J. Dutta, H. van Bakel, L. L. Coffey

The paper reports the detection of human H1N1 influenza A virus in northern elephant seals in California in 2019, indicating continued zoonotic transmission from humans to marine mammals.

bioRxiv · Nov 4, 2022 · PreprintMicrobiology

Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.

T. Kehrer, A. Cupic, C. Ye, S. Yildiz, M. Bouhhadou, N. A. Crossland, E. Barrall, P. Cohen, A. Tseng, T. Cagatay, R. Rathnasinghe, D. Flores, S. Jangra, F. Alam, N. Mena, , L. Miorin

This study shows SARS-CoV-2 ORF6 disrupts nucleo-cytoplasmic trafficking, inhibits IFN signaling, and modulates viral protein expression, with variant polymorphisms affecting its function.

bioRxiv · Oct 18, 2022Microbiology

Mapping SARS-CoV-2 antigenic relationships and serological responses

S. H. Wilks, B. Muhlemann, X. Shen, S. Tureli, E. B. LeGresley, A. Netzl, M. A. Caniza, J. N. Chacaltana-Huarcaya, V. M. Corman, X. Daniell, M. B. Datto, F. S. Dawood, T. N. Denny, C. Drosten, R. A. M. Fouchier, , D. J. Smith

The paper uses antigenic cartography to analyze cross-reactivity among SARS-CoV-2 variants and human sera, identifying amino acid substitutions and immunodominance patterns affecting immune escape and vaccine efficacy.

bioRxiv · Jan 28, 2022Immunology

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

J. A. Duty, T. A. Kraus, H. Zhou, Y. Zhang, N. Shaabani, S. Yildiz, N. Du, A. Singh, L. Miorin, D. Li, K. Stegman, S. I. Ophir, X. Cao, K. Atanasoff, R. Lim, , R. Allen

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology

Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent in vitro activity against the SARS-CoV-2 Omicron variant

R. Rosales, B. L. McGovern, M. L. Rodriquez, D. K. Rai, R. D. Cardin, A. S. Anderson, E. M. Sordillo, H. van Bakel, V. Simon, A. Garcia-Sastre, K. M. White

This study evaluates the antiviral activity of nirmatrelvir, molnupiravir, and remdesivir against the SARS-CoV-2 Omicron variant and confirms their potency.

bioRxiv · Jan 17, 2022 · PreprintMicrobiology

SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage

A. Escalera, A. S. Gonzalez-Reiche, S. Aslam, I. Mena, R. L. Pearl, M. Laporte, A. Fossati, R. Rathnasinghe, H. Alshammary, A. van de Guchte, M. Bouhaddou, T. Kehrer, L. Zuliani-Alvarez, D. A. Meekins, V. Balaraman, , T. Aydillo

This study shows SARS-CoV-2 variants of concern have mutations that increase spike cleavage and fusogenic capacity, enhancing viral transmission and cell entry.

bioRxiv · Aug 5, 2021 · PreprintMicrobiology

Novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidase

E. Kirkpatrick Roubidoux, M. McMahon, J. M. Carreno, C. Capuano, K. Jiang, V. Simon, H. van Bakel, P. Wilson, F. Krammer

This study identifies novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidase and characterizes escape mutations and their impact on viral fitness.

bioRxiv · Feb 26, 2021 · PreprintMicrobiology

Respiratory tract explant infection dynamics of influenza A virus in California sea lions, northern elephant seals, and rhesus macaques

H. Liu, M. Plancarte, E. E. Ball, C. M. Weiss, O. Gonzales-Viera, K. Holcomb, Z.-M. Ma, A. M. Allen, J. R. Reader, P. J. Duignan, B. Halaska, Z. Khan, D. Kriti, J. Dutta, H. van Bakel, , L. L. Coffey

This study uses respiratory tract explants from marine mammals and rhesus macaques to compare influenza A virus infection kinetics across species.

bioRxiv · Oct 15, 2020Microbiology

Complete genome screening of clinical MRSA isolates identifies lineage diversity and provides full resolution of transmission and outbreak events

M. J. Sullivan, D. R. Altman, K. I. Chacko, B. Ciferri, E. Webster, T. R. Pak, G. Deikus, M. Lewis-Sandari, Z. Khan, C. Beckford, A. Rendo, F. Samaroo, R. Sebra, R. Karam-Howlin, T. Dingle, , H. van Bakel

This study uses long-read sequencing to analyze MRSA genomes, revealing lineage diversity and detailed transmission dynamics in an outbreak.

bioRxiv · May 21, 2019 · PreprintMicrobiology

Discovery Of UFO Proteins: Human-Virus Chimeric Proteins Generated During Influenza Virus Infection

Y. Ma, M. Angel, G. Wang, J. S. Y. Ho, N. Zhao, J. Noel, N. Moshkina, J. Gibbs, J. Wei, B. Rosenberg, J. Johnson, M. Chang, Z. Peralta, N. Krogan, C. Benner, , I. Marazzi

The paper identifies host-virus chimeric proteins, called UFOs, generated during influenza virus infection through the translation of viral 5UTRs using host transcripts.

bioRxiv · Apr 8, 2019 · PreprintMicrobiology

Avian influenza viruses in wild birds: virus evolution in a multi-host ecosystem

D. Venkatesh, M. J. Poen, T. M. Bestebroer, R. D. Scheuer, O. Vuong, M. Chkhaidze, A. Machablishvili, J. Mamuchadze, L. Ninua, N. B. Fedorova, R. A. Halpin, X. Lin, A. Ransier, T. B. Stockwell, D. E. Wentworth, , N. S. Lewis

This study tracks avian influenza virus evolution in wild birds across three migratory flyways in Georgia, revealing subtype diversity, reassortment patterns, and genetic relationships with global AIV populations.

bioRxiv · Mar 17, 2018Microbiology