Author

M. P. Weekes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 10 Approach:experimental assay· 9 Organism:human· 8 Research Focus:host-pathogen & immune response· 7 Approach:biophysical modeling· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2

Frequent Co-Authors

R. Antrobus· 6 shared K. Nightingale· 3 shared L. Nobre· 3 shared R. j. Stanton· 3 shared A. Fletcher-Etherington· 2 shared A. J. Davison· 2 shared J. Houghton· 2 shared J. Nichols· 2 shared

Activity by Year

2019-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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6 shared papersMicrobiology

R. Antrobus

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Epstein-Barr Virus BALF0/1 Subverts the Caveolin and ERAD Pathways to Target B-cell Receptor Complexes for Degradation

S. P. T. Yiu, M. P. Weekes, B. E. Gewurz

This paper identifies that EBV's BALF0/1 protein degrades B-cell receptor complexes by subverting caveolin and ERAD pathways, enhancing viral secretion.

Proceedings of the National Academy of Sciences · Jan 23, 2025Peer-reviewedMicrobiology

Large-scale proteomic analysis of T. spiralis muscle-stage ESPs identifies a novel upstream motif for in silico prediction of secreted products

B. Nash, W. F. Gregory, R. R. White, A. Protasio, S. P. Gygi, M. E. Selkirk, M. P. Weekes, K. Artavanis-Tsakonas

This study identifies a novel upstream motif in T. spiralis muscle-stage ESPs that can predict secreted proteins, using proteomic and computational methods.

Frontiers in Parasitology · Jan 25, 2023Peer-reviewedCell Biology

Selective modulation of cell surface proteins during vaccinia infection: implications for immune evasion strategies

D. M. Depierreux, A. F. Altenburg, L. Soday, A. Fletcher-Etherington, R. Antrobus, B. J. Ferguson, M. P. Weekes, G. L. Smith

This study quantifies PM protein modulation during vaccinia infection, identifying downregulated immune ligands and upregulated decoy receptors, revealing immune evasion strategies.

bioRxiv · Oct 6, 2021 · PreprintMicrobiology

IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses

M. Clement, J. L. Forbester, M. Marsden, P. Sabberwal, D. Wellington, S. Dimonte, K. Harcourt, S. Clare, Z. Yin, L. Nobre, R. Antrobus, B. Jin, M. Chen, S. Makvandi-Nejad, J. A. Lindborg, , I. Humphreys

This study shows IFITM3 limits viral pathogenesis by regulating Nogo-B-mediated TLR responses and cytokine production in dendritic cells.

bioRxiv · Jul 23, 2021 · PreprintImmunology

A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signalling

A. Vasou, K. Nightingale, V. Cetkovska, J. Scheler, C. G. Bamford, J. Andrejeva, U. Schwarz-Linek, R. E. Randall, J. McLauchlan, M. P. Weekes, D. Bogunovic, D. J. Hughes

The paper identifies a new function of ISG15 in stabilizing USP18 through non-covalent interactions, revealing a mechanism that controls type I IFN signalling.

bioRxiv · Jun 1, 2021 · PreprintImmunology

Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

K. Nightingale, C. A. Fielding, C. Zerbe, L. Hunter, M. Potts, A. Fletcher-Etheringon, L. Nobre, E. C. Y. Wang, B. L. Strang, J. Houghton, R. Antrobus, N. M. Suarez, J. Nichols, A. J. Davison, R. J. Stanton, M. P. Weekes

This study identifies HCMV protein RL1 as a viral antagonist that degrades SLFN11 via CRL4 E3 ubiquitin ligase, revealing SLFN11's role in restricting HCMV infection.

bioRxiv · May 14, 2021Microbiology

Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes

B. J. Ravenhill, L. Soday, J. Houghton, R. Antrobus, M. P. Weekes

The paper identifies cell surface protein markers for classical, intermediate, and non-classical monocytes using mass spectrometry and biotinylation.

bioRxiv · Feb 20, 2020Immunology

Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor

A. Fletcher-Etherington, L. Nobre, K. Nightingale, R. J. Antrobus, J. Nichols, A. J. Davison, R. J. Stanton, M. P. Weekes

This paper identifies HCMV protein pUL36 as a dual inhibitor of apoptotic and necroptotic cell death by degrading MLKL and preventing caspase 8 activation.

bioRxiv · Feb 3, 2020Microbiology

Herpes simplex virus-1 pUL56 degrades GOPC to alter the plasma membrane proteome

T. K. Soh, C. T. R. Davies, J. Muenzner, V. Connor, C. R. Bouton, H. G. Barrow, C. Smith, E. Emmott, R. Antrobus, S. C. Graham, M. P. Weekes, C. M. Crump

This study identifies HSV-1 pUL56 as a protein that degrades GOPC, altering the plasma membrane proteome by affecting signaling receptors.

bioRxiv · Aug 8, 2019Microbiology

Temporal proteomic analysis of BK polyomavirus infection reveals virus-induced G2 arrest and highly effective evasion of innate immune sensing

L. G. Caller, C. Davies, R. Antrobus, P. Lehner, M. P. Weekes, C. Crump

This study uses temporal proteomic analysis to show BKPyV induces G2 arrest and evades innate immune sensing during infection.

bioRxiv · Apr 7, 2019Microbiology