R. Arora

Proteolytic degradation of atrial sarcomere proteins underlies contractile defects in atrial fibrillation

This study identifies proteolytic degradation of atrial sarcomere proteins as a mechanism underlying contractile defects in atrial fibrillation.

Revealing Molecular Mechanisms of Early-Onset Tongue Cancer by Spatial Transcriptomics

This study identifies distinct spatial transcriptomic features and molecular mechanisms in early-onset tongue cancer compared to older patients.

Insights into the genomic features, lifestyle and therapeutic potential of B1 sub-cluster mycobacteriophages

This study functionally annotates and experimentally characterizes B1 sub-cluster mycobacteriophages, revealing their genomic features, lifestyle, and therapeutic potential against drug-resistant M. smegmatis.

Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response

This study uses spatial transcriptomics to analyze tumor core and edge regions in OSCC, revealing distinct transcriptional profiles and their clinical implications across multiple cancers.

Repertoire-Scale Measures of Antigen Binding

The paper introduces a framework to assess immune repertoires based on epitope-binding properties of antibodies and TCRs, showing its application in distinguishing immune responses and stratifying cohorts.

Endometriotic Organoids: A Novel In Vitro Model of Endometriotic Lesion Development.

This study develops endometriotic organoids to model epithelial-stromal interactions and cell invasion in endometriotic lesion development, finding increased invasion with estrogen or proinflammatory macrophages.

Sequestration of LINE-1 in novel cytosolic bodies by MOV10 restricts retrotransposition

The paper shows MOV10 sequesters L1 retroelements into cytosolic bodies, reducing their retrotransposition in Dicer_KO mouse embryonic stem cells.

AGO1 regulates pericentromeric regions in mouse embryonic stem cells

This study shows that AGO1 depletion in mESCs causes redistribution of H3K9me3 and HP1 away from pericentromeres and upregulates major satellite transcripts.

An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amenable to Dexamethasone Therapy

This study identifies distinct neutrophil states in COVID-19 compared to bacterial ARDS and shows dexamethasone alters these states, reducing mortality risk.

TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells.

This study inhibits TERRA transcription in ALT cells, showing it destabilizes telomere integrity and initiates BIR, supporting telomere elongation.

Regions of Highly Recurrent Electrogram Morphology at Sites of Low Cycle Length Accurately Reflect Arrhythmogenic Substrate for Atrial Fibrillation - Implications For a New, Mechanism Guided Therapeutic Approach for Atrial Fibrillation

This study identifies electrogram morphology recurrence as a marker of arrhythmogenic substrate in atrial fibrillation, suggesting it could guide targeted ablation therapy.

Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment

This study shows that ARID1A in endometrial epithelium is critical for gland function and early pregnancy by regulating Foxa2 and the LIF-STAT3-EGR1 pathway.

INTEGRINS MEDIATE PLACENTAL EXTRACELLULAR VESICLE TRAFFICKING TO LUNG AND LIVER IN VIVO

The paper identifies maternal cells targeted by placental extracellular vesicles and shows integrin-dependent trafficking to lung and liver, with potential genetic alteration of maternal cells.

3D synthetic microscaffolds promote homogenous expression of NANOG in mouse embryonic stem cells

This paper introduces 3D synthetic microscaffolds that enhance homogenous NANOG and OCT4 expression in mouse ESCs compared to 2D cultures.

Merkel cell polyomavirus in Merkel cell carcinoma: Integration sites and involvement of the KMT2D tumor suppressor gene

The paper identifies MCV integration sites in Merkel cell carcinoma using whole exome sequencing and finds no highly recurrent sites, with chromosome 5 most frequent and integration enriched near oncogenic transcription factor binding sites.

Private Antibody Repertoires Are Public

The paper demonstrates overwhelming functional overlap between antibody repertoires from 20 individuals, showing shared antigen-binding capacities that decline with age.

SARS-CoV2 Testing: The Limit of Detection Matters

This study evaluates how the limit of detection (LoD) of SARS-CoV-2 assays affects false negative rates using 27,500 test results, finding a 13% increase in false negatives per 10-fold LoD increase.

A metabolomics study of ascorbic acid-induced in situ freezing tolerance in spinach (Spinacia oleracea L.)

This study investigates how ascorbic acid improves freezing tolerance in spinach by analyzing metabolic changes and physiological responses.

Disruption of NOX2-dependent Oxidative Injury with a Targeted Gene-Therapy Approach Prevents Atrial Fibrillation in a Canine Model

This study shows that disrupting NOX2-dependent oxidative injury with gene therapy prevents atrial fibrillation in dogs.

Repertoire-Based Diagnostics Using Statistical Biophysics

This paper introduces a descriptor-based MaxEnt model for classifying immune repertoires, achieving high accuracy in influenza vaccination status classification with limited samples.

Immunological Diversity with Similarity

The paper develops a framework for functional immunological diversity using binding data and applies it to reveal patterns in immunological memory and aging, showing functional diversity captures more information than raw diversity.