Author

K. Shaffer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:virus· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Parekh· 3 shared S. Hui· 3 shared V. Rayaprolu· 3 shared A. Parvate· 2 shared C. Hariharan· 2 shared E. O. Saphire· 2 shared H. Callaway· 2 shared A. Balaram· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

D. Parekh

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Author profile →

3 papers

Recent·Most cited

A broadly-neutralizing antibody against Ebolavirus glycoprotein that potentiates the breadth and neutralization potency of other antibodies

F. R. Donnellan, V. Rayaprolu, P. Rijal, V. O'Dowd, A. Parvate, H. Callaway, C. Hariharan, D. Parekh, S. Hui, K. Shaffer, R. Diaz Avalos, K. Hastie, L. Schimanski, H. Müller-Kräuter, T. Strecker, , S. J. Draper

The paper identifies two broadly neutralizing antibodies against Ebolavirus glycoprotein and shows that one enhances the neutralization breadth and potency of other antibodies.

bioRxiv · Jun 21, 2024Immunology

Structure of the Inmazeb cocktail and resistance to escape against Ebola virus

V. Rayaprolu, B. Fulton, A. Rafique, E. Arturo, D. Williams, C. Hariharan, H. Callaway, A. Parvate, S. L. Schendel, D. Parekh, S. Hui, K. Shaffer, K. E. Pascal, E. Wloga, S. Giordano, , E. O. Saphire

The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.

bioRxiv · Oct 11, 2022Biophysics

Glycan shield of the ebolavirus envelope glycoprotein GP

W. Peng, V. Rayaprolu, A. D. Parvate, M. F. Pronker, S. Hui, D. Parekh, K. Shaffer, X. Yu, E. O. Saphire, J. Snijder

This study profiles the site-specific glycosylation patterns of ebolavirus GP using mass spectrometry, revealing complex N-, O-, and C-linked glycans that contribute to the glycan shield and restrict antibody neutralization.

bioRxiv · Feb 7, 2022Biochemistry