Author

S. Hui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Biophysics· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cell type annotation· 3 Organism:virus· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2

Frequent Co-Authors

E. O. Saphire· 3 shared D. Parekh· 2 shared G. Oeltzschner· 2 shared K. Shaffer· 2 shared S. Tapper· 2 shared V. Rayaprolu· 2 shared A. Baum· 1 shared A. Bukreyev· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiophysics

E. O. Saphire

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure

S. Stanley, X. Wang, Q. Liu, Y. Y. Kwon, A. M. Frey, N. D. Hicks, A. J. Vickers, S. Hui, S. M. Fortune

This study investigates the evolutionary adaptation of Mycobacterium tuberculosis lactate dehydrogenase (LldD2) under host pressure, showing its role in metabolic flexibility and virulence.

bioRxiv · Oct 9, 2023 · PreprintMicrobiology

IL-6 is dispensable for causing cachexia in the colon carcinoma 26 model

Y.-Y. Kwon, S. Hui

This study shows that IL-6 is not required for cachexia in the C26 colon carcinoma model, as IL-6 knockout tumors still induce cachexia despite reduced tumor growth.

bioRxiv · May 2, 2023 · PreprintCell Biology

A liver-specific mitochondrial carrier that controls gluconeogenesis and energy expenditure

J.-S. Yook, Z. H. Taxin, B. Yuan, S. Oikawa, C. Auger, B. Mutlu, P. Puigserver, S. Hui, S. Kajimura

This study identifies SLC25A47 as a liver-specific mitochondrial carrier that regulates gluconeogenesis and energy expenditure by controlling pyruvate flux and FGF21 expression.

bioRxiv · Dec 6, 2022 · PreprintPhysiology

Structure of the Inmazeb cocktail and resistance to escape against Ebola virus

V. Rayaprolu, B. Fulton, A. Rafique, E. Arturo, D. Williams, C. Hariharan, H. Callaway, A. Parvate, S. L. Schendel, D. Parekh, S. Hui, K. Shaffer, K. E. Pascal, E. Wloga, S. Giordano, , E. O. Saphire

The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.

bioRxiv · Oct 11, 2022Biophysics

Glycan shield of the ebolavirus envelope glycoprotein GP

W. Peng, V. Rayaprolu, A. D. Parvate, M. F. Pronker, S. Hui, D. Parekh, K. Shaffer, X. Yu, E. O. Saphire, J. Snijder

This study profiles the site-specific glycosylation patterns of ebolavirus GP using mass spectrometry, revealing complex N-, O-, and C-linked glycans that contribute to the glycan shield and restrict antibody neutralization.

bioRxiv · Feb 7, 2022Biochemistry

The Macromolecular MR Spectrum in Healthy Aging

S. Hui, T. Gong, H. J. Zoellner, Y. Song, S. Murali-Manohar, G. Oeltzschner, M. Mikkelsen, S. Tapper, Y. Chen, M. Saleh, E. C. Porges, W. Chen, G. Wang, R. A. E. Edden

This study acquires and analyzes the macromolecular MR spectrum in healthy adults across ages 20-69, finding no significant age or sex-related changes in macromolecule signals.

bioRxiv · Aug 27, 2021 · PreprintBioengineering

Comparison of different linear-combination modelling algorithms for short-TE proton spectra

H. J. Zollner, M. Povazan, S. Hui, S. Tapper, R. A. Edden, G. Oeltzschner

This paper compares three linear-combination modelling algorithms for short-TE proton MRS spectra, finding moderate agreement in metabolite estimates but significant variability in Glx and mI across algorithms.

bioRxiv · Jun 5, 2020 · PreprintBiochemistry

Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody

B. R. West, A. Z. Wec, C. L. Moyer, M. L. Fusco, P. A. Illinykh, K. Huang, R. James, A. Herbert, S. Hui, A. S. Wirchnianski, E. Goodwin, M. J. Aman, L. M. Walker, J. M. Dye, A. Bukreyev, , E. O. Saphire

The paper determines the structure of a broadly neutralizing antibody against ebolavirus, identifies a conserved epitope, and explains factors affecting its activity against related viruses.

bioRxiv · Aug 19, 2018Immunology