Author

K. E. Pascal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:cryo-EM· 1 Organism:multiple species· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

A. Baum· 3 shared A. Rafique· 2 shared C. A. Kyratsous· 2 shared E. Wloga· 2 shared R. Copin· 2 shared S. Giordano· 2 shared A. Barve· 1 shared A. Coppola· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

A. Baum

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structure of the Inmazeb cocktail and resistance to escape against Ebola virus

V. Rayaprolu, B. Fulton, A. Rafique, E. Arturo, D. Williams, C. Hariharan, H. Callaway, A. Parvate, S. L. Schendel, D. Parekh, S. Hui, K. Shaffer, K. E. Pascal, E. Wloga, S. Giordano, , E. O. Saphire

The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.

bioRxiv · Oct 11, 2022Biophysics

REGEN-COV protects against viral escape in preclinical and human studies

R. Copin, A. Baum, E. Wloga, K. E. Pascal, S. Giordano, B. O. Fulton, A. Zhou, N. Negron, K. Lanza, N. Chan, A. Coppola, J. Chiu, M. Ni, G. S. Atwal, A. Romero Hernandez, , C. A. Kyratsous

This study shows that REGEN-COV, a combination of non-competing antibodies, provides broad coverage against SARS-CoV-2 variants and prevents the emergence of new variants in clinical and preclinical settings.

bioRxiv · Mar 10, 2021 · PreprintMicrobiology

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

L. Yurkovetskiy, X. Wang, K. E. Pascal, C. Tompkins-Tinch, T. Nyalile, Y. Wang, A. Baum, W. E. Diehl, A. Dauphin, C. Carbone, K. Veinotte, S. B. Egri, S. F. Schaffner, J. E. Lemieux, J. Munro, , J. Luban

This study shows the D614G SARS-CoV-2 spike protein variant is more infectious but has reduced ACE2 affinity and altered trimer conformation, affecting viral entry and antibody neutralization.

bioRxiv · Jul 4, 2020Microbiology