Author

D. Parekh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:virus· 2 Research Focus:cell type annotation· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

E. O. Saphire· 3 shared K. Shaffer· 2 shared S. Hui· 2 shared S. L. Schendel· 2 shared V. Rayaprolu· 2 shared A. Baum· 1 shared A. D. Parvate· 1 shared A. Parvate· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersMicrobiology

E. O. Saphire

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Intracellular Ebola Virus nucleocapsid assembly revealed by in situ cryo-electron tomography.

R. Watanabe, D. Zyla, D. Parekh, C. Hong, Y. Jones, S. L. Schendel, W. Wan, G. Castillon, E. O. Saphire

This study uses cryo-electron tomography to reveal the structure of the intracellular Ebola virus nucleocapsid, identifying a new outer layer of NP complexed with VP35 and conserved assembly interfaces.

bioRxiv · Dec 1, 2023Microbiology

Structure of the Inmazeb cocktail and resistance to escape against Ebola virus

V. Rayaprolu, B. Fulton, A. Rafique, E. Arturo, D. Williams, C. Hariharan, H. Callaway, A. Parvate, S. L. Schendel, D. Parekh, S. Hui, K. Shaffer, K. E. Pascal, E. Wloga, S. Giordano, , E. O. Saphire

The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.

bioRxiv · Oct 11, 2022Biophysics

Glycan shield of the ebolavirus envelope glycoprotein GP

W. Peng, V. Rayaprolu, A. D. Parvate, M. F. Pronker, S. Hui, D. Parekh, K. Shaffer, X. Yu, E. O. Saphire, J. Snijder

This study profiles the site-specific glycosylation patterns of ebolavirus GP using mass spectrometry, revealing complex N-, O-, and C-linked glycans that contribute to the glycan shield and restrict antibody neutralization.

bioRxiv · Feb 7, 2022Biochemistry