Author

K. Tasken

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:deconvolution· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Brech· 1 shared A. Frigessi· 1 shared A. J. Arribas· 1 shared A. K. Hilli· 1 shared A. Köhn-Luque· 1 shared A. Pfefferle· 1 shared A. R. Mato· 1 shared A. Urban· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperImmunology

A. Brech

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Functional testing of PI3K inhibitors stratifies responders to idelalisib and identifies treatment vulnerabilities in idelalisib-refractory/intolerant chronic lymphocytic leukemia

Y. Yin, P. Athanasiadis, L. Karlsen, A. Urban, I. Murali, S. M. Fernandes, A. J. Arribas, A. K. Hilli, K. Tasken, F. Bertoni, A. R. Mato, E. Normant, J. R. Brown, G. E. Tjonnfjord, T. Aittokallio, S. S. Skanland

This study uses ex vivo drug sensitivity testing to identify treatment responses and vulnerabilities in chronic lymphocytic leukemia patients, showing that pan-PI3Ki and combinations with venetoclax can be effective in idelalisib-refractory/intolerant cases.

bioRxiv · Apr 14, 2022 · PreprintCancer Biology

Phenotypic deconvolution in heterogeneous cancer cell populations using drug screening data

A. Köhn-Luque, E. M. Myklebust, D. S. Tadele, M. Giliberto, L. Schmiester, J. Noory, E. Harivel, P. Arsenteva, S. M. Mumenthaler, F. Schjesvold, K. Tasken, J. M. Enserink, K. Leder, A. Frigessi, J. Foo

This paper introduces PhenoPop, a method to deconvolve tumor heterogeneity using drug screening data, identifying subpopulations with differential drug responses and their frequencies.

bioRxiv · Jan 17, 2022Cancer Biology

Modulation of Secretory Lysosomes During NK Cell Education Leads to Accumulation of Granzyme B and Enhanced Functional Potential

J. P. Goodridge, B. Jacobs, M. L. Satersmoen, D. Clement, T. Clancy, E. Skarpen, A. Brech, J. Landskron, C. Grimm, A. Pfefferle, L. Meza-Zepeda, S. Lorenz, M. T. Wiiger, W. E. Louch, E. H. Ask, , K.-J. Malmberg

This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.

bioRxiv · Jul 4, 2018Immunology