HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomography
S. Li, X. Jia, T. Niu, X. Zhang, C. Qi, W. Xu, H. Deng, F. Sun, G. Ji
The paper introduces HOPE-SIM, a cryo-CLEM system that improves targeting precision for cryo-ET by integrating 3D SIM and software, achieving 150 nm correlation accuracy.
bioRxiv · Sep 16, 2022 · PreprintBiophysics