Author

J. A. Lederer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Organism:human· 7 Research Focus:differential expression· 6 Assay:flow cytometry· 5 Assay:scRNA-seq· 5 Approach:experimental assay· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3

Frequent Co-Authors

D. A. Rao· 6 shared N. Hacohen· 4 shared A. Filer· 3 shared C. Nusbaum· 3 shared D. J. Lieb· 3 shared K. Slowikowski· 3 shared K. Wei· 3 shared L. T. Donlin· 3 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

D. A. Rao

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Aging and interferon gamma response drive the phenotype of neutrophils in the inflamed joint

R. Grieshaber-Bouyer, T. Exner, N. S. Hackert, F. A. Radtke, S. A. Jelinsky, O. Halyabar, A. Wactor, E. Karimizadeh, J. Schettini, A. H. Jonsson, D. A. Rao, L. A. Henderson, C. Mueller-Tidow, H.-M. Lorenz, G. Wabnitz, , P. A. Nigrovic

This study identifies transcriptional and phenotypic changes in synovial fluid neutrophils from arthritis patients, highlighting IFNγ response and aging as key drivers.

bioRxiv · Nov 16, 2021 · PreprintImmunology

Longitudinal immune cell profiling in early systemic lupus erythematosus

T. Sasaki, S. Bracero, J. Keegan, L. Chen, Y. Cao, E. Stevens, Y. Qu, G. Wang, J. Nguyen, S. E. Alves, J. A. Lederer, K. H. Costenbader, D. A. Rao

This study tracks immune cell changes in early systemic lupus erythematosus using mass cytometry and identifies longitudinal shifts in Tfh cells and CXCL10.

bioRxiv · Nov 8, 2021Immunology

Single Cell RNA-seq and Mass Cytometry Reveals a Novel and a Targetable Population of Macrophages in Idiopathic Pulmonary Fibrosis

E. A. Ayaub, S. Poli, J. Ng, T. S. Adams, J. C. Schupp, L. Quesada, F. Poli, C. Cosme, R. Matthew, J. Martinez, X. Liang, J. Villalba, J. A. Lederer, S. G. Chu, B. Raby, , I. Rosas

The paper identifies a novel, targetable macrophage population in idiopathic pulmonary fibrosis using single-cell RNA-seq, CyTOF, and flow cytometry.

bioRxiv · Jan 4, 2021 · PreprintCell Biology

The immune cell landscape in kidneys of lupus nephritis patients

A. Arazi, D. A. Rao, C. C. Berthier, A. Davidson, Y. Liu, P. J. Hoover, A. Chicoine, T. M. Eisenhaure, A. H. Jonsson, S. Li, D. J. Lieb, E. P. Browne, A. Noma, D. Sutherby, S. Steelman, , B. Diamond

This study uses single-cell RNA-seq to analyze immune cell subsets in lupus nephritis kidneys, identifying pro-inflammatory and resolving responses and potential therapeutic targets.

bioRxiv · Jul 7, 2018Immunology

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry

F. Zhang, K. Wei, K. Slowikowski, C. Y. Fonseka, D. A. Rao, S. Kelly, S. M. Goodman, D. Tabechian, L. B. Hughes, K. Salomon-Escoto, G. F. M. Watts, W. Apruzzese, D. J. Lieb, D. L. Boyle, A. M. Mandelin, , S. Raychaudhuri

The paper identifies key inflammatory cell states in RA synovial tissues using integrated single-cell and mass cytometry data from patient samples.

bioRxiv · Jun 20, 2018Immunology

High dimensional analyses of cells dissociated from cryopreserved synovial tissue

L. T. Donlin, D. A. Rao, K. Wei, K. Slowikowski, M. J. McGeachy, J. D. Turner, N. Meednu, F. Mizoguchi, M. Gutierrez-Arcelus, D. J. Lieb, J. Keegan, K. Muskat, J. Hillman, C. Rozo, E. Ricker, , M. B Brenner

This paper establishes a protocol for dissociating cryopreserved synovial tissue to obtain viable cells with preserved transcriptomes and surface markers, enabling high-dimensional analysis of rheumatoid arthritis pathology.

bioRxiv · Mar 19, 2018Immunology

Single Cell Transcriptomics And Flow Cytometry Reveal Disease-Associated Fibroblast Subsets In Rheumatoid Arthritis

F. Mizoguchi, K. Slowikowski, J. L. Marshall, K. Wei, D. A. Rao, S. K. Chang, H. N. Nguyen, E. H. Noss, J. D. Turner, B. E. Earp, P. E. Blazar, J. Wright, B. P. Simmons, L. T. Donlin, G. D. Kalliolias, , M. B. Brenner

The paper identifies disease-associated fibroblast subsets in rheumatoid arthritis using single-cell transcriptomics and flow cytometry, revealing subset-specific markers and functional differences.

bioRxiv · May 26, 2017Immunology