Author

L. Hangartner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Organism:non-human primate· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Assay:CITE-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. B. Ward· 3 shared D. R. Burton· 3 shared R. Nedellec· 3 shared B. Murrell· 2 shared B. Nogal· 2 shared C. A. Cottrell· 2 shared D. Burton· 2 shared D. J. Irvine· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

A. B. Ward

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge

M. W. Grunst, H. M. Gil, A. G. Grandea, B. J. Snow, R. Andrabi, R. Nedellec, I. Burton, N. M. Clark, S. K. Janaka, N. K. Keles, R. V. Moriarty, A. M. Weiler, S. Capuano, C. M. Fennessey, T. C. Friedrich, , D. T. Evans

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

bioRxiv · Nov 14, 2023Microbiology

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

J. H. Lee, H. J. Sutton, C. A. Cottrell, I. Phung, G. Ozorowski, L. M. Sewall, R. Nedellec, C. Nakao, M. Silva, S. T. Richey, J. L. Torres, W.-H. Lee, E. Georgeson, M. Kubitz, S. Hodges, , S. Crotty

This study shows that germinal center B cells can persist and continue to mutate for 29 weeks after a single immunization, leading to long-lasting antibody responses.

bioRxiv · Dec 20, 2021 · PreprintImmunology

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

B. Nogal, M. Bianchi, C. Cottrell, R. N. Kirchdoerfer, L. M. Sewall, H. L. Turner, F. Zhao, D. Sok, D. Burton, L. Hangartner, A. B. Ward

This study maps polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines and identifies epitopes associated with neutralization breadth.

bioRxiv · Nov 7, 2019Immunology

Vaccine-induced protection from homologous Tier 2 simian-human immunodeficiency virus challenge in nonhuman primates

M. G. Pauthner, J. P. Nkolola, C. Havenar-Daughton, B. Murrell, S. M. Reiss, R. Bastidas, J. Prevost, R. Nedellec, B. von Bredow, P. Abbink, C. A. Cottrell, D. W. Kulp, T. Tokatlian, B. Nogal, M. Bianchi, , D. R. Burton

This study shows that high serum neutralizing antibody titers from Env protein vaccination protect rhesus macaques from Tier 2 SHIV challenge, with ~1:500 ID50 titers providing over 90% protection.

bioRxiv · Oct 29, 2018Immunology

Reprogramming the antigen specificity of B cells using genome-editing technologies

J. E. Voss, A. Gonzalez-Martin, R. Andrabi, R. P. Fuller, B. Murrell, L. E. McCoy, K. Porter, D. Huang, W. Li, D. Sok, K. Le, B. Briney, M. Chateau, G. Rogers, L. Hangartner, , D. Burton

This study reprograms B cells to express HIV-specific BCRs by editing immunoglobulin genes with CRISPR-Cas9, enabling improved anti-HIV neutralizing activity.

bioRxiv · Oct 29, 2018Immunology