A. Dubey

ELONGATED HYPOCOTYL 5 (HY5) and POPEYE (PYE) Regulate Intercellular Iron Transport in Plants.

This study shows HY5 and PYE regulate intercellular iron transport in plants by interacting and repressing Fe transport genes.

Algorithm for automatic detection of insulin granule exocytosis in human β-cells

The paper develops an image-processing algorithm for detecting insulin granule exocytosis in human β-cells, showing improved efficiency and accuracy compared to existing methods.

Activin E is a TGFβ ligand that signals specifically through activin receptor-like kinase 7.

This study identifies Activin E as a TGFβ ligand that signals through ALK7, using canonical activin receptors and SMAD2/3 pathways, similar to Activin C.

Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function

This study shows that E2 protein interaction with BRD4's CTM and TopBP1 is essential for HPV16's mitotic chromatin association and plasmid segregation, offering therapeutic targets for viral genome targeting.

Bile acid fitness determinants of a Bacteroides fragilis isolate from a human pouchitis patient

This study identifies genes and pathways in B. fragilis that affect its fitness in bile acids, using a barcoded mutant library and transcriptomic analysis.

Human papillomavirus 16 E2 interaction with TopBP1 is required for E2 and viral genome stability during the viral life cycle.

This paper shows that HPV16 and HPV11 E2 proteins require interaction with TopBP1 for stability, and disrupting this interaction with CK2 inhibitors like CX4945 promotes viral genome integration and could be a therapeutic strategy.

Glucocorticoid signaling mediates CD8+ T cell memory differentiation

The paper shows glucocorticoids enhance CD8+ T cell memory differentiation by promoting tissue-homing TRM cells and metabolic shifts via AMPK and STAT3/5 signaling.

Selective estrogen receptor modulators limit alphavirus infection by targeting the viral capping enzyme nsP1

This study shows that SERMs inhibit alphavirus infection by targeting the viral capping enzyme nsP1, with antiviral effects observed in cell culture and mice.

Targeting conserved viral virulence determinants by single domain antibodies to block SARS-CoV2 infectivity

This study identifies single domain antibodies that neutralize SARS-CoV2 by targeting the cleavage site and receptor binding domain of the spike protein, showing their stability and effectiveness in blocking infectivity.

A slow-exchange conformational switch regulates off-target cleavage by high-fidelity Cas9

This study identifies a conformational switch in Cas9 that reduces off-target cleavage by enabling REC3 domain scanning for proper base pairing.

Evaluating the ecological impacts of pesticide seed treatments on arthropod communities in a grain crop rotation

This study evaluates the ecological impacts of pesticide seed treatments on arthropod communities in a grain crop rotation, finding variable effects on community structure and suggesting potential for recovery delays.