CTLA-4 tail fusion enhances CAR-T anti-tumor immunity
X. Zhou, H. Cao, S.-Y. Fang, R. D. Chow, K. Tang, M. Majety, M. Bai, M. B. Dong, P. A. Renauer, X. Shang, K. Suzuki, A. Levchenko, S. Chen
This study enhances CAR-T cell efficacy by fusing CTLA-4 cytoplasmic tails to CARs, improving anti-tumor responses in a leukemia model.
bioRxiv · Mar 14, 2023 · PreprintImmunology