M. Bai

PENet: A phenotype encoding network for automatic extraction and representation of morphological discriminative features

PENet is a deep learning model that automatically extracts and encodes morphological features into hash codes, showing effectiveness in feature extraction and image retrieval across beetle datasets.

Perturbomics of tumor-infiltrating NK cells

This study identifies genetic factors limiting NK cell function in tumors using CRISPR screens and single-cell sequencing, highlighting CALHM2 as a target for improving NK cell-based therapies.

CTLA-4 tail fusion enhances CAR-T anti-tumor immunity

This study enhances CAR-T cell efficacy by fusing CTLA-4 cytoplasmic tails to CARs, improving anti-tumor responses in a leukemia model.

Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function

The paper identifies ADA as a metabolic regulator that enhances CAR-T cell function and tumor clearance through improved metabolism and reduced exhaustion.

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages

This paper designs and characterizes bispecific antibodies effective against multiple SARS-CoV-2 Omicron sublineages and determines their cryo-EM structures.

Potent and specific human monoclonal antibodies against SARS-CoV-2 Omicron variant by rapid mRNA immunization of humanized mice

This study develops RAMIHM, a method to generate potent human monoclonal antibodies against SARS-CoV-2 Omicron using mRNA immunization of humanized mice, identifying three highly effective antibodies.

Natural killer-like B cells promote Th17 cell differentiation and exacerbate rheumatoid arthritis

This study identifies natural killer-like B cells as pathogenic in rheumatoid arthritis by promoting Th17 differentiation and disease severity.

New insights into the earlier evolutionary history of epiphytic macrolichens

The paper identifies a Jurassic fossil as an epiphytic macrolichen, suggesting macrolichen diversity predates the Cenozoic diversification of extant lineages.

Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies

This study identifies the structural and molecular mechanisms of two neutralizing antibodies against FMDV, showing they disrupt virus-receptor interactions and provide prophylactic and therapeutic benefits.

The conserved ER-transmembrane protein TMEM39 coordinates with vesicular COPII to promote collagen secretion and prevent ER stress

This study identifies TMEM39 as a conserved ER protein that facilitates collagen secretion and prevents ER stress by interacting with COPII components.

Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrels

This study identifies a naturally occurring ATP5G1 variant in Arctic ground squirrels that enhances mitochondrial function and cell resilience to metabolic stress through a specific amino acid substitution.

Broadly Conserved Roles of TMEM-131 Family Proteins in Intracellular Collagen Assembly and Secretory Cargo Trafficking

This study identifies TMEM-131 family proteins as conserved regulators of collagen assembly and secretion across species, showing their role in ER stress and collagen production.

Conserved Roles of C. elegans and Human MANFs in Sulfatide Binding and Cytoprotection

This study identifies C. elegans MANF orthologue, shows it binds sulfatide, and demonstrates sulfatide-dependent cytoprotection in both worms and mammalian cells.