Author

A. A. Holder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 13 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 16 Research Focus:cell type annotation· 14 Organism:plant (other)· 10 Research Focus:cell signaling & trafficking· 8 Assay:proteomics· 7 Organism:mouse· 5 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:development & morphogenesis· 3

Frequent Co-Authors

D. Brady· 14 shared R. Tewari· 14 shared M. Zeeshan· 13 shared E. Rea· 6 shared K. G. Le Roch· 6 shared R. Pandey· 6 shared S. Abel· 6 shared s. vaughan· 6 shared

Activity by Year

2019-2024 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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14 shared papersCell Biology

D. Brady

Mutual co-authors in cluster

Author profile →

16 papers

Recent·Most cited

Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation

M. Zeeshan, R. Rashpa, D. J. Ferguson, G. Mckeown, R. Nugmanova, A. K. Subodhi, R. Beyeler, S. L. Pashley, R. Markus, D. Brady, M. Roques, A. R. Bottrill, A. M. Fry, A. Pain, s. vaughan, , R. Tewari

This study identifies NEK1's role in organizing the MTOC and ensuring kinetochore attachment during rapid mitosis in Plasmodium male gamete formation.

bioRxiv · Feb 5, 2024 · PreprintCell Biology

Plasmodium ARK2-EB1 axis drives the unconventional spindle dynamics, scaffold formation, and chromosome segregation of sexual transmission stages

M. Zeeshan, E. Rea, S. Abel, K. Vukusic, R. Markus, D. Brady, A. A. Eze, R. Rashpa, A. Balestra, A. Bottrill, M. Brochet, D. Guttery, I. M. Tolic, A. A. Holder, K. G. Le Roch, , R. Tewari

bioRxiv · Jan 29, 2023 · PreprintCell Biology

Plasmodium SAS4/CPAP is a flagellum basal body component during male gametogenesis but is not essential for parasite transmission

M. Zeeshan, D. Brady, R. Markus, S. Vaughan, D. Ferguson, A. A. Holder, R. Tewari

This study investigates the role of SAS4/CPAP in Plasmodium male gametogenesis, showing it is part of the basal body but not essential for gamete formation or parasite transmission.

bioRxiv · Dec 3, 2021 · PreprintCell Biology

Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle

M. Zeeshan, R. Rashpa, D. J. P. Ferguson, S. Abel, Z. Chahine, D. Brady, s. vaughan, C. A. Moores, K. G. Le Roch, M. Brochet, A. A. Holder, R. Tewari

The paper identifies key kinesins involved in the malaria parasite life cycle in mammalian and mosquito hosts, showing kinesin-13 is essential for growth in mammals while others are critical for mosquito transmission.

bioRxiv · May 26, 2021Cell Biology

Protein Phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages

M. Zeeshan, R. Pandey, A. K. SUBUDHI, D. J. P. Ferguson, G. Kaur, R. Rashpa, R. Nugmanova, D. Brady, A. Bottrill, S. Vaughan, M. Brochet, M. Bollen, A. Pain, A. A. Holder, D. S. Guttery, R. Tewari

The paper investigates the role of Protein Phosphatase 1 (PP1) in atypical mitotic and meiotic divisions during Plasmodium sexual stages, suggesting PP1 inhibitors could block parasite transmission.

bioRxiv · Jan 15, 2021Cell Biology

Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress, and invasion

A. C. Schlott, E. Knuepfer, J. L. Green, P. Hobson, A. J. Borg, J. Morales-Sanfrutos, A. J. Perrin, A. P. Snijders, E. W. Tate, A. A. Holder

This study shows that inhibiting N-myristoylation in Plasmodium falciparum blocks parasite development, egress, and invasion through multiple mechanisms.

bioRxiv · Dec 16, 2020 · PreprintMicrobiology

MRE11 is crucial for malaria transmission and its absence affects expression of interconnected networks of key genes essential for life

D. Guttery, A. Ramaprasad, D. Ferguson, M. Zeeshan, R. Pandey, D. Brady, A. A. Holder, A. Pain, R. Tewari

This study shows that MRE11 is essential for Plasmodium development in mosquitoes, with its absence causing transcriptional changes in critical biological processes and blocking parasite transmission.

bioRxiv · Aug 24, 2020Cell Biology

Plasmodium berghei kinesin-5 associates with the spindle apparatus during cell division and is important for efficient production of infectious sporozoites

M. Zeeshan, D. Brady, R. R. Stanway, C. Moores, A. A. Holder, R. Tewari

This study identifies kinesin-5's role in Plasmodium berghei cell division, showing it is essential for sporozoite production and associated with the spindle apparatus.

bioRxiv · Jul 3, 2020 · PreprintCell Biology

Plasmodium DEH is ER-localized and crucial for oocyst mitotic division during malaria transmission

D. S. Guttery, R. Pandey, D. Ferguson, R. Wall, D. Brady, D. Gupta, A. A. Holder, R. Tewari

This study identifies DEH as an ER-localized protein essential for oocyst mitotic division in Plasmodium berghei, disrupting sporogony and parasite transmission.

bioRxiv · Jul 1, 2020 · PreprintCell Biology

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of Plasmodium berghei during gametogony and parasite transmission.

A. C. Balestra, M. Zeeshan, E. Rea, C. Pasquarello, L. A. Brusini, T. Mourier, A. K. Subudhi, P. Arboit, N. Klages, R. Pandey, D. Brady, S. Vaughan, A. A. Holder, A. Pain, D. Ferguson, , M. Brochet

This study identifies CRK5 as a critical regulator of atypical DNA replication in Plasmodium berghei during gametogony and mosquito transmission.

eLife · Jun 22, 2020Peer-reviewedMicrobiology

Real-time dynamics of Plasmodium NDC80 reveals unusual modes of chromosome segregation during parasite proliferation

M. Zeeshan, R. Pandey, D. J. P. Ferguson, E. C. Tromer, R. Markus, S. Abel, D. Brady, E. Daniel, R. R. Stanway, A. R. Bottrill, K. G. Le Roch, A. A. Holder, R. F. Waller, D. S. Guttery, R. Tewari

The paper studies the dynamics of the NDC80 complex in Plasmodium berghei to reveal unique chromosome segregation mechanisms during parasite proliferation.

bioRxiv · May 12, 2020Cell Biology

Plasmodium condensin core subunits (SMC2/SMC4) mediate atypical mitosis and are essential for parasite proliferation and transmission

R. Pandey, S. Abel, M. Boucher, R. J. Wall, M. Zeeshan, E. Rea, A. Freville, X. M. Lu, D. Brady, E. Daniel, R. R. Stanway, S. Wheatley, G. Batugedara, T. Hollin, A. R. Bottrill, , R. Tewari

bioRxiv · Dec 22, 2019Cell Biology

Protein ubiquitylation is essential for the schizont to merozoite transition in Plasmodium falciparum blood-stage development

Y. Wu, V. Encheva, J. L. Green, E. Lasonder, A. Prommaban, S. Kunzelmann, E. Christodoulou, M. Grainger, N. Truongvan, S. Bothe, V. Sharma, W. Song, I. Pinzuti, C. Uthaipibull, S. Srichairatanakool, , A. A. Holder

This paper identifies ubiquitylation sites in Plasmodium falciparum and shows that ubiquitylation is essential for the schizont to merozoite transition.

bioRxiv · Sep 4, 2019 · PreprintMicrobiology

Kinesin-8B controls basal body function and flagellum formation and is key to malaria parasite transmission

M. Zeeshan, D. J. P. Ferguson, S. Abel, A. Burrrell, E. Rea, D. Brady, E. Daniel, M. Delves, S. Vaughan, A. A. Holder, K. G. Le Roch, C. A. Moores, R. Tewari

This study identifies kinesin-8B's role in malaria parasite flagellum formation and transmission by analyzing its localization and function during gamete development.

bioRxiv · Jul 2, 2019Cell Biology

Plasmodium Kinesin-8X associates with mitotic spindles and is essential for oocyst development during parasite proliferation and transmission

M. Zeeshan, F. Shilliday, T. Liu, S. Abel, T. Mourier, D. J. P. Ferguson, E. Rea, R. R. Stanway, M. Roques, D. Williams, E. Daniel, D. Brady, A. J. Roberts, A. A. Holder, A. Pain, , R. Tewari

This study identifies Plasmodium Kinesin-8X as essential for endomitotic division during oocyst development and parasite transmission.

bioRxiv · Jun 29, 2019Cell Biology

Systematic analysis of Plasmodium myosins reveals differential expression, localization and function in invasive and proliferative parasite stages

R. J. Wall, M. ZEESHAN, N. J. Katris, R. Limenitakis, E. Rea, J. Stock, D. Brady, R. F. Waller, A. A. Holder, R. Tewari

This study systematically analyzes Plasmodium myosins, revealing their differential expression, localization, and functional roles in invasive and proliferative parasite stages.

bioRxiv · Jun 14, 2019Cell Biology