M. Crestani

Unraveling Glioblastoma Heterogeneity: Introducing SP2G Method for Identifying Invasive Sub-Populations

The paper introduces SP2G, a method to identify invasive sub-populations in glioblastoma cells by analyzing their motility on gridded micropatterns and linking it to molecular markers.

SP2G: an imaging and analysis pipeline revealing the inter and intra-patient migratory diversity of glioblastoma

SP2G identifies invasive glioblastoma sub-populations through an in vivo mimicry platform and imaging analysis, revealing intra-patient heterogeneity in cell motility.

Mechanically induced topological transition of spectrin regulates its distribution in the mammalian cortex

This study shows spectrin in mammalian cells can transition between different topological structures under mechanical stress, adapting to protect the cell cortex.

Emergent oscillations during cellular directional decision-making on junctions

The paper presents a theoretical model predicting oscillations in cellular polarization during directional decision-making at junctions, validated experimentally in two cell types.

PIP4K2B is a mechanosensor and induces heterochromatin-driven nuclear softening through UHRF1.

The paper identifies PIP4K2B as a mechanosensor that induces nuclear softening via UHRF1, affecting YAP activity and cell motility in cancer.

Adaptive mechanoproperties characterize glioblastoma fitness for invasion

The paper identifies FMN1 as a driver of glioblastoma invasiveness by linking it to increased cell stiffness, mechanical forces, and stochastic motility.