A. Poli

T-Cell-Mediated Killing in Glioblastoma Organoids induced by Adenoviral Delivery of the CIITA Transgene

This study shows that adenoviral delivery of CIITA enhances T-cell mediated killing of glioblastoma organoids, with some MHC-II-independent immune responses observed.

Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts

This study characterizes the tumor microenvironment in glioblastoma patient-derived xenografts and patient tumors, revealing phenotypic heterogeneity in microglia and their functional adaptations.

Force-biased nuclear import sets nuclear-cytoplasmic volumetric coupling by osmosis

The paper measures cytoplasmic and nuclear volumes in human cells and finds cytoplasm grows exponentially while nucleus grows linearly, showing cytoskeletal forces influence nuclear import and volumetric coupling via osmosis.

PIP4K2B is a mechanosensor and induces heterochromatin-driven nuclear softening through UHRF1.

The paper identifies PIP4K2B as a mechanosensor that induces nuclear softening via UHRF1, affecting YAP activity and cell motility in cancer.

FAM13A regulates KLRG1 expression and interferon gamma production of natural killer cells

This study shows that FAM13A depletion increases KLRG1 and reduces IFN-gamma production in NK cells, leading to increased lung metastases in a mouse model.