Author

M. Dodel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:cell signaling & trafficking· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

F. K. Mardakheh· 7 shared M. Dermit· 3 shared A. Shkumatava· 2 shared C. Vias· 2 shared D. Ginsberg· 2 shared E. Shaulian· 2 shared E. Stern· 2 shared I. Soni· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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7 shared papersCell Biology

F. K. Mardakheh

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Author profile →

8 papers

Recent·Most cited

STAG3 promotes exit from pluripotency through post-transcriptional mRNA regulation in the cytoplasm.

S. Weeks, D. Pezic, M. Dodel, K. Shah, A. Bhamra, S. Surinova, S. Henderson, T. V. Sharp, F. K. Mardakheh, S. HADJUR

This study shows STAG3 regulates post-transcriptional mRNA in mESCs, promoting exit from pluripotency by interacting with RNA-binding proteins and affecting mRNA stability.

bioRxiv · May 31, 2024 · PreprintCell Biology

The stress-induced lincRNA JUNI is a critical factor for cancer cell survival whose interactome is a prognostic signature in clear cell renal cell carcinoma

V. Kumar, X. Sabate-Cadenas, I. Soni, E. Stern, C. Vias, D. Ginsberg, C. Roma-Mateo, R. Pulido, M. Dodel, F. K. Mardakheh, I. Z. Ben-Dov, A. Shkumatava, E. Shaulian

This paper identifies JUNI, a stress-induced lncRNA critical for cancer cell survival, and shows its interactome predicts prognosis in clear cell renal cell carcinoma.

bioRxiv · Oct 23, 2023 · PreprintCell Biology

TREX reveals proteins that bind to specific RNA regions in living cells

M. Dodel, G. Guiducci, M. Dermit, S. Krishnamurthy, L. Stojic, F. K. Mardakheh

TREX identifies RNA-binding proteins interacting with specific RNA regions in living cells, revealing novel interactions in 45S rRNA and U1 snRNA.

bioRxiv · Jun 30, 2023Cell Biology

Cancer cells survival is dependent on the lincRNA JUNI

V. Kumar, X. Sabate-Cadenas, I. Soni, E. Stern, C. Vias, D. Ginsberg, M. Dodel, F. K. Mardakheh, A. Shkumatava, E. Shaulian

The paper identifies JUNI as a lincRNA essential for cancer cell survival and patient prognosis, showing its role in regulating c-Jun and interacting with DUSP14.

bioRxiv · Jun 21, 2022 · PreprintCell Biology

An RNA-binding switch drives ribosome biogenesis and tumorigenesis downstream of RAS oncogene

M. S. Azman, M. Dodel, F. Capraro, R. Faraway, M. Dermit, W. Fan, J. Ule, F. K. Mardakheh

This study identifies Nucleolin as a key mediator of RAS-driven ribosome biogenesis and tumorigenesis through enhanced RNA-binding activity.

bioRxiv · Dec 16, 2021Cancer Biology

An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus

A. Navickas, H. Asgharian, J. Winkler, L. Fish, K. Garcia, D. Markett, M. Dodel, B. Culbertson, S. Miglani, T. Joshi, P. Nguyen, S. Zhang, N. Stevers, H.-W. Hwang, F. Mardakheh, , H. Goodarzi

The paper identifies HNRNPC and PABPC4 as regulators of alternative polyadenylation that suppress breast cancer metastasis by controlling mRNA translation.

bioRxiv · Oct 4, 2021Cancer Biology

Centrosome amplification mediates small extracellular vesicles secretion via lysosome disruption

S. A. Godinho, S. D. Adams, J. Csere, G. D'angelo, E. P. Carter, T. Arnandis, M. Dodel, H. Kocher, R. Grose, G. Raposo, F. K. Mardakheh

The paper shows centrosome amplification in pancreatic cancer cells increases small extracellular vesicle secretion through lysosomal dysfunction, promoting tumor invasion.

bioRxiv · Aug 19, 2020Cell Biology

Subcellular mRNA localization regulates ribosome biogenesis in migrating cells

M. Dermit, M. Dodel, F. C. Y. Lee, M. S. Azman, H. Schwenzer, J. L. Jones, S. P. Blagden, J. Ule, F. K. Mardakheh

The paper shows that subcellular localization of RP-mRNAs via LARP6 enhances ribosome biogenesis during cell migration and supports cancer progression through EMT.

bioRxiv · Dec 2, 2019Cell Biology