M. Engel

Alzheimer's disease induced neurons bearing PSEN1 mutations exhibit reduced excitability

This study investigates how PSEN1 mutations in Alzheimer's disease affect neuronal excitability using iPSC-derived neurons and finds reduced excitability and altered Kv/Nav channel currents in mutant neurons.

Mechanisms of Innate Immune Injury in Arrhythmogenic Cardiomyopathy

This study identifies NFκB signaling in cardiac myocytes as a driver of myocardial injury and arrhythmias in a mouse model of arrhythmogenic cardiomyopathy.

A 3D bioprintable hydrogel with tuneable stiffness for exploring cells encapsulated in matrices of differing stiffnesses

This study develops a tunable 3D bioprintable hydrogel to investigate how matrix stiffness and biological motifs affect cell behavior.

A high-throughput 3D bioprinted cancer cell migration and invasion model with versatile and broad biological applicability

This paper develops a high-throughput 3D bioprinted model for studying cancer cell migration and invasion, enabling real-time analysis and drug screening.

Historical biogeography of early diverging termite lineages (Isoptera: Teletisoptera)

This paper reconstructs the historical biogeography of early diverging termite lineages using genetic data, finding that their distribution resulted from both over-water dispersals and land bridge migrations.

Transoceanic voyages of drywood termites (Isoptera: Kalotermitidae) inferred from extant and extinct species

This study uses phylogenetic analysis to infer the transoceanic dispersal history and foraging evolution of Kalotermitidae termites, finding that dispersal and human activity shaped their global distribution.

Enabling high throughput target-based drug discovery in 3D cell cultures through novel bioprinting workflow

This paper demonstrates a 3D cell culture platform integrated with high throughput bioprinting and screening assays for drug discovery, showing compatibility with traditional 2D assays and improved drug response predictability.

Identity domains in complex behavior: Toward a biology of personality

The paper introduces a mathematical framework to study individual differences in behavior and gene expression in mice, validated using high-throughput behavioral data.