M. Fukuda

Pigmentation level of human iPSC-derived retinal pigment epithelium cell does not indicate a specific gene expression profile

The paper analyzes the relationship between pigmentation level and gene expression in human iPSC-derived RPE cells, finding no specific gene expression profile correlates with color intensity.

Structural basis for ion selectivity in potassium-selective channelrhodopsins

The paper determines the cryo-EM structures of two K+-selective channelrhodopsins, revealing a unique mechanism for K+ selectivity distinct from canonical K+ channels.

Liver-secreted fluorescent blood plasma markers enable chronic imaging of microcirculation

This paper introduces a method to chronically image blood microcirculation using liver-secreted fluorescent proteins, enabling long-term observation of vascular functions in mice.

TBC1D18, a novel Rab5-GAP, coordinates endosome maturation together with Mon1

This study identifies TBC1D18 as a novel Rab5-GAP that works with Mon1 to regulate endosome maturation by inactivating Rab5.

Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

The paper presents the cryo-EM structure of ChRmine, revealing unique architectural features and provides insights into its conduction mechanism and potential for optogenetic applications.

Identification of a new, Rab14-dependent, endo-lysosomal pathway

The paper identifies a new endocytic pathway dependent on Rab14 that delivers cargo to late endosomes/lysosomes independently of Rab5 and Rab7.

RBD11, a bioengineered Rab11-binding module for visualizing and analyzing endogenous Rab11

This study develops RBD11, a bioengineered Rab11-binding domain that visualizes endogenous Rab11 without disrupting its function and demonstrates its use in analyzing Rab11-dependent processes.

An Autophagy-Dependent Tubular Lysosomal Network Synchronizes Degradative Activity Required for Muscle Remodeling

The paper identifies a tubular autolysosomal network in Drosophila muscle remodeling that synchronizes degradative activity, marked by Syntaxin 17 and dependent on autophagy.

Rab34 GTPase mediates ciliary membrane biogenesis in the intracellular ciliogenesis pathway

This study identifies Rab34 as a mediator of intracellular ciliogenesis, showing its role in ciliary vesicle formation and sheath marking, distinct from the extracellular pathway.

Glycosylphosphatidylinositol-anchoring is required for the proper transport and glycosylation of classical arabinogalactan protein precursor in tobacco BY-2 cells

This study shows that GPI-anchoring is essential for the correct transport and glycosylation of an AGP precursor in tobacco cells.

ALIX and ceramide differentially control polarized exosome release from epithelial cells

The paper identifies two distinct mechanisms for polarized exosome release from epithelial cells: ALIX-Syntenin1-Syndecan1 for apical exosomes and ceramide production for basolateral exosomes.

Tuba activates Cdc42 during neuronal polarization downstream of the small GTPase Rab8a

This study identifies Tuba as a GEF that links Rab8a and Cdc42 in neuronal polarization, showing a feedback loop essential for axon specification.