J. Ellis

Mutation of two intronic nucleotide alters RNA structure and dynamics, inhibiting MBNL1 and RBFOX1 regulated splicing of the Insulin Receptor

The paper shows that mutating two intronic nucleotides alters RNA structure and dynamics, disrupting MBNL1 and RBFOX1 regulation of INSR exon 11 splicing.

Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across tumor types

The paper evaluates mitochondrial OXPHOS expression and function across murine tumors and normal tissues, finding lower OXPHOS levels in tumors compared to normal and high OXPHOS organs.

Pathology of natural infection with highly pathogenic avian influenza virus (H5N1) clade 2.3.4.4b in wild terrestrial mammals in the United States in 2022

The paper reports the first cases of H5N1 avian influenza in wild mammals in the US, showing neurological symptoms and lesions linked to bird-to-mammal spillover.

Inferring transmission routes for foot-and-mouth disease virus within a cattle herd using approximate Bayesian computation

This study uses approximate Bayesian computation to infer transmission routes of FMDV within a cattle herd, finding direct contact contributes most infections but environmental contamination also plays a role.

Advanced physiological maturation of iPSC-derived human cardiomyocytes using an algorithm-directed optimization of defined media components

This study develops a novel medium for iPSC-derived cardiomyocytes using differential evolution to enhance maturation, validated through multiomic analysis.

Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccine

This study designs a pan-sarbecovirus vaccine targeting conserved epitopes and shows it induces cross-neutralizing antibodies and T-cell responses in mice and humans.

Protoplast fusion in Bacillus species produces frequent, unbiased, genome-wide homologous recombination

This study uses protoplast fusion in Bacillus species to show genome-wide, unbiased homologous recombination without recombination hotspots or genetic distance effects.

Alternative polyadenylation is a determinant of oncogenic Ras function

This study shows that alternative polyadenylation regulates oncogenic Ras function by affecting transcript 3' UTR length in both C. elegans and human cells.

Characterisation of the transcriptome and proteome of SARS-CoV-2 using direct RNA sequencing and tandem mass spectrometry reveals evidence for a cell passage induced in-frame deletion in the spike glycoprotein that removes the furin-like cleavage site